Evidence map›Paper›PMID 25601993›Full record

ArticleThe American journal of tropical medicine and hygiene2015

Therapeutic efficacy of chloroquine for the treatment of uncomplicated Plasmodium falciparum in Haiti after many decades of its use.

Bernard A Okech, Alexandre Existe, Jean R Romain, Gladys Memnon, Yves Saint Victor, Madsen Beau de Rochars, Mark Fukuda

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The American journal of tropical medicine and hygiene, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Investigations of socioeconomic factors associated with follow-up compliance with malaria treatment in Haiti.Revista panamericana de salud publica = Pan American journal of public health · 2021
    Article
  5. Establishing a National Molecular Surveillance Program for the Detection ofThe American journal of tropical medicine and hygiene · 2020
    Article
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  10. Haiti's Commitment to Malaria Elimination: Progress in the Face of Challenges, 2010-2016.The American journal of tropical medicine and hygiene · 2017
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Bernard A OkechDepartment of Environmental and Global Health, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Laboratoire National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti; L'Hospital Saint Croix de Leogane, Pere Thevenot 1, Leogane, Haiti; Blanchard Clinic, Family Health Ministries Haiti, Port-au-Prince, Haiti; Department of Health Services Research, Management and Policy, University of Florida, Gainesville, Florida; Armed Forces Health Sciences Surveillance Center, Silver Spring, Maryland bokech@ufl.edu.
Alexandre ExisteDepartment of Environmental and Global Health, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Laboratoire National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti; L'Hospital Saint Croix de Leogane, Pere Thevenot 1, Leogane, Haiti; Blanchard Clinic, Family Health Ministries Haiti, Port-au-Prince, Haiti; Department of Health Services Research, Management and Policy, University of Florida, Gainesville, Florida; Armed Forces Health Sciences Surveillance Center, Silver Spring, Maryland.
Jean R RomainDepartment of Environmental and Global Health, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Laboratoire National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti; L'Hospital Saint Croix de Leogane, Pere Thevenot 1, Leogane, Haiti; Blanchard Clinic, Family Health Ministries Haiti, Port-au-Prince, Haiti; Department of Health Services Research, Management and Policy, University of Florida, Gainesville, Florida; Armed Forces Health Sciences Surveillance Center, Silver Spring, Maryland.
Gladys MemnonDepartment of Environmental and Global Health, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Laboratoire National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti; L'Hospital Saint Croix de Leogane, Pere Thevenot 1, Leogane, Haiti; Blanchard Clinic, Family Health Ministries Haiti, Port-au-Prince, Haiti; Department of Health Services Research, Management and Policy, University of Florida, Gainesville, Florida; Armed Forces Health Sciences Surveillance Center, Silver Spring, Maryland.
Yves Saint VictorDepartment of Environmental and Global Health, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Laboratoire National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti; L'Hospital Saint Croix de Leogane, Pere Thevenot 1, Leogane, Haiti; Blanchard Clinic, Family Health Ministries Haiti, Port-au-Prince, Haiti; Department of Health Services Research, Management and Policy, University of Florida, Gainesville, Florida; Armed Forces Health Sciences Surveillance Center, Silver Spring, Maryland.
Madsen Beau de RocharsDepartment of Environmental and Global Health, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Laboratoire National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti; L'Hospital Saint Croix de Leogane, Pere Thevenot 1, Leogane, Haiti; Blanchard Clinic, Family Health Ministries Haiti, Port-au-Prince, Haiti; Department of Health Services Research, Management and Policy, University of Florida, Gainesville, Florida; Armed Forces Health Sciences Surveillance Center, Silver Spring, Maryland.
Mark FukudaDepartment of Environmental and Global Health, University of Florida, Gainesville, Florida; Emerging Pathogens Institute, University of Florida, Gainesville, Florida; Laboratoire National de Santé Publique (LNSP), Ministère de la Santé Publique et de la Population, Port-au-Prince, Haiti; L'Hospital Saint Croix de Leogane, Pere Thevenot 1, Leogane, Haiti; Blanchard Clinic, Family Health Ministries Haiti, Port-au-Prince, Haiti; Department of Health Services Research, Management and Policy, University of Florida, Gainesville, Florida; Armed Forces Health Sciences Surveillance Center, Silver Spring, Maryland.
University of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chloroquine (CQ) has been used for malaria treatment in Haiti for several decades, but reports of CQ resistance are scarce. The efficacy of CQ in patients with uncomplicated Plasmodium falciparum undergoing treatment in Haiti was evaluated. Malaria patients were enrolled, treated with CQ, and monitored over a 42-day period. The treatment outcomes were evaluated on day 28 by microscopy. The P. falciparum slide-confirmed rate was 9.5% (121 of 1,277). Malaria infection was seasonal, with peak observations between October and January; 88% (107 of 121) of patients consented to participate. Sixty patients successfully completed the 42-day follow-up, whereas 47 patients withdrew consent or were lost to follow-up. The mean parasite density declined rapidly within the first few days after treatment. Seven patients did not clear their malaria infections and were clinically asymptomatic; therefore, they were considered late parasitological failures. About 90% (95% confidence interval = 84.20-97.90) of patients had no detectable parasitemia by day 28 and remained malaria-free to day 42. Testing for recrudescence, reinfection, and CQ serum levels was not done in the seven patients, and therefore, their CQ resistance status is unresolved. CQ resistance surveillance by patient follow-up, in vitro drug sensitivity studies, and molecular markers is urgently needed in Haiti.

Indexed as

AntimalarialsChloroquineDrug ResistanceFemaleHaitiHumansMalaria, FalciparumMalePlasmodium falciparumTime FactorsAntimalarialsChloroquine

Identifiers

PMID25601993
PMCPMC4350545
OpenAlexW2000012288

What OpenQuestion holds

Textmetadata
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.