ReviewFrontiers in immunology2014
Metabolic syndrome and the immunological affair with the blood-brain barrier.
Review in Frontiers in immunology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- The Impact of Biological Sex And High-Fat High-Fructose Diet on Brain Dysfunction in an Animal Model of Sepsis.Molecular neurobiology · 2025Article
- Regulation of the blood-brain barrier function by peripheral cues in health and disease.Metabolic brain disease · 2024Review
- Metabolic Syndrome Status Changes and Cognitive Functioning: Insights from the Lifelines Cohort Study.The journal of prevention of Alzheimer's disease · 2024Article
- Neuro-Vulnerability in Energy Metabolism Regulation: A Comprehensive Narrative Review.Nutrients · 2023Review
- Long COVID-19 and Health-Related Quality of Life of Mild Cases in Korea: 3-Months Follow-up of a Single Community Treatment Center.Journal of Korean medical science · 2022Article
- The Relationship Between the Blood-Brain-Barrier and the Central Effects of Glucagon-Like Peptide-1 Receptor Agonists and Sodium-Glucose Cotransporter-2 Inhibitors.Diabetes, metabolic syndrome and obesity : targets and therapy · 2022Review
- Does Neuroinflammation Underlie the Cognitive Changes Observed With Dietary Interventions?Frontiers in neuroscience · 2022Review
- Unhealthy Dieting During the COVID-19 Pandemic: An Opinion Regarding the Harmful Effects on Brain Health.Frontiers in nutrition · 2022Article
- Cardiac Autonomic Neuropathy: A Progressive Consequence of Chronic Low-Grade Inflammation in Type 2 Diabetes and Related Metabolic Disorders.International journal of molecular sciences · 2020Review
- Immuno-metabolic impact of the multiple sclerosis patients' sera on endothelial cells of the blood-brain barrier.Journal of neuroinflammation · 2020Article
- Age-Associated Changes in the Immune System and Blood⁻Brain Barrier Functions.International journal of molecular sciences · 2019Review
- Importance of AT1 and AT2 receptors in the nucleus of the solitary tract in cardiovascular responses induced by a high-fat diet.Hypertension research : official journal of the Japanese Society of Hypertension · 2019Article
- Connecting Metainflammation and Neuroinflammation Through the PTN-MK-RPTPβ/ζ Axis: Relevance in Therapeutic Development.Frontiers in pharmacology · 2019Review
- "Beige" Cross Talk Between the Immune System and Metabolism.Frontiers in endocrinology · 2019Article
- Contributions of polygenic risk for obesity to PTSD-related metabolic syndrome and cortical thickness.Brain, behavior, and immunity · 2017Article
- Traumatic Stress and Accelerated Cellular Aging: From Epigenetics to Cardiometabolic Disease.Current psychiatry reports · 2017Review
- Cytokine signature associated with disease severity in chronic fatigue syndrome patients.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Posttraumatic Stress Disorder as a Catalyst for the Association Between Metabolic Syndrome and Reduced Cortical Thickness.Biological psychiatry · 2016Article
- High-fat diet feeding differentially affects the development of inflammation in the central nervous system.Journal of neuroinflammation · 2016Article
- Secret talk between adipose tissue and central nervous system via secreted factors-an emerging frontier in the neurodegenerative research.Journal of neuroinflammation · 2016Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Epidemiological studies reveal an increased incidence of obesity worldwide, which is associated with increased prevalence and severity of cognitive disorders. The blood-brain barrier (BBB) represents the interface between the peripheral circulation and the brain, and plays a fundamental role in the cross-talk between these two compartments. The homeostatic function of the BBB is the protection of the brain from peripheral insult/inflammation. Alterations in the function of the BBB lead to pathologies of the central nervous system. Recently, metabolic imbalance has been shown to be an important risk factor associated with the decline of BBB integrity and function. This has direct etiological consequences on a variety of cerebrovascular and neurodegenerative pathologies with great impact to society. Priority areas for future preclinical research include strategies to improve clinicians' ability to diagnose, prevent, and manage BBB abnormalities. In sharp contrast with epidemiological studies and clinical needs, little is known about the mechanisms that link metabolic syndrome to BBB functionality and cognitive disorders. Our view is that immune responses caused by metabolic stress might play a major role in this conundrum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.