Evidence map›Paper›PMID 25601825›Full record

ArticleFrontiers in neuroscience2014

Feasibility of simultaneous whole-brain imaging on an integrated PET-MRI system using an enhanced 2-point Dixon attenuation correction method.

Udunna C Anazodo, Jonathan D Thiessen, Tracy Ssali, Jonathan Mandel, Matthias Günther, John Butler, William Pavlosky, Frank S Prato, R Terry Thompson, Keith S St Lawrence

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PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Attenuation correction for human PET/MRI studies.Physics in medicine and biology · 2020
    Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. [AJNR. American journal of neuroradiology · 2017
    Article
  10. Article
  11. An Overview of Multimodal Neuroimaging Using Nanoprobes.International journal of molecular sciences · 2017
    Review
  12. Review
  13. Role of Hybrid Brain Imaging in Neuropsychiatric Disorders.Diagnostics (Basel, Switzerland) · 2015
    Review
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Udunna C AnazodoLawson Health Research Institute London, ON, Canada ; Medical Biophysics, Western University London, ON, Canada.
Jonathan D ThiessenLawson Health Research Institute London, ON, Canada ; Medical Biophysics, Western University London, ON, Canada.
Tracy SsaliLawson Health Research Institute London, ON, Canada ; Medical Biophysics, Western University London, ON, Canada.
Jonathan MandelDiagnostic Imaging, St. Joseph's Health Care London, ON, Canada.
Matthias GüntherFraunhofer Institute for Medical Image Computing MEVIS Bremen, Germany.
John ButlerLawson Health Research Institute London, ON, Canada.
William PavloskyDiagnostic Imaging, St. Joseph's Health Care London, ON, Canada.
Frank S PratoLawson Health Research Institute London, ON, Canada ; Medical Biophysics, Western University London, ON, Canada.
R Terry ThompsonLawson Health Research Institute London, ON, Canada ; Medical Biophysics, Western University London, ON, Canada.
Keith S St LawrenceLawson Health Research Institute London, ON, Canada ; Medical Biophysics, Western University London, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate a potential approach for improved attenuation correction (AC) of PET in simultaneous PET and MRI brain imaging, a straightforward approach that adds bone information missing on Dixon AC was explored.

methodsBone information derived from individual T1-weighted MRI data using segmentation tools in SPM8, were added to the standard Dixon AC map. Percent relative difference between PET reconstructed with Dixon+bone and with Dixon AC maps were compared across brain regions of 13 oncology patients. The clinical potential of the improved Dixon AC was investigated by comparing relative perfusion (rCBF) measured with arterial spin labeling to relative glucose uptake (rPETdxbone) measured simultaneously with (18)F-flurodexoyglucose in several regions across the brain.

resultsA gradual increase in PET signal from center to the edge of the brain was observed in PET reconstructed with Dixon+bone. A 5-20% reduction in regional PET signals were observed in data corrected with standard Dixon AC maps. These regional underestimations of PET were either reduced or removed when Dixon+bone AC was applied. The mean relative correlation coefficient between rCBF and rPETdxbone was r = 0.53 (p < 0.001). Marked regional variations in rCBF-to-rPET correlation were observed, with the highest associations in the caudate and cingulate and the lowest in limbic structures. All findings were well matched to observations from previous studies conducted with PET data reconstructed with computed tomography derived AC maps.

conclusionAdding bone information derived from T1-weighted MRI to Dixon AC maps can improve underestimation of PET activity in hybrid PET-MRI neuroimaging.

Indexed as

18F-fluorodexoyglucosearterial spin labelingASLattenuation correctioncerebral blood flowFDGglucose uptakePET-MRI

Identifiers

PMID25601825
PMCPMC4283546

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.