Evidence map›Paper›PMID 25601818›Full record

ArticleTetrahedron letters2015

Facile syntheses of functionalized toll-like receptor 7 agonists.

Babatope Akinbobuyi, Matthew R Byrd, Charles A Chang, Mysa Nguyen, Zacharie J Seifert, Anne-Laure Flamar, Gerard Zurawski, Katherine C Upchurch, SangKon Oh, Stephen H Dempsey and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Tetrahedron letters, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Babatope AkinbobuyiDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
Matthew R ByrdDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
Charles A ChangInstitute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA.
Mysa NguyenDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
Zacharie J SeifertDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA.
Anne-Laure FlamarBaylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
Gerard ZurawskiInstitute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA ; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
Katherine C UpchurchInstitute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA.
SangKon OhInstitute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA ; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
Stephen H DempseyDepartment of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
Thomas J EnkeDepartment of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
John LeDepartment of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
Hunter J WinsteadDepartment of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
José R BoquínDepartment of Chemistry, Augustana College, 639 38 Street, Rock Island, IL 61201, USA.
Robert R KaneDepartment of Chemistry and Biochemistry, Baylor University, One Bear Place #97348, Waco, TX 76798, USA ; Institute of Biomedical Studies, Baylor University, One Bear Place #97224, Waco, TX 76798, USA ; Baylor Institute for Immunology Research, Baylor Research Institute, 3434 Live Oak Street, Dallas, TX 75204, USA.
Baylor University · US

Funding

Targeting Dendritic Cells for Enhanced Musocal ImmunityU19AI057234 · NIAID · BAYLOR RESEARCH INSTITUTE · PI LEGRAND, ROGER · 2003 to 2013
$49.2M
NIAID NIH HHS U19 AI057234
6 · The paper itself

Abstract

Protein conjugates of toll-like receptor 7 agonists have been shown to elicit powerful immune responses. In order to facilitate our studies in this area our group has developed efficient syntheses for a number of functionalized derivatives that retain immune stimulatory activity.

Indexed as

Adenine derivativesImmune activationToll-like receptorVaccines

Identifiers

PMID25601818
PMCPMC4296738
OpenAlexW1967228067

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.