Evidence map›Paper›PMID 25601779›Full record

ReviewNature reviews. Neuroscience2015

Redefining the cerebellar cortex as an assembly of non-uniform Purkinje cell microcircuits.

Nadia L Cerminara, Eric J Lang, Roy V Sillitoe, Richard Apps

Abstract readReview
In one paragraph

Review in Nature reviews. Neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 179 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
179citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

179 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Critical period plasticity enables credit assignment.bioRxiv : the preprint server for biology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Divergent somatic mutation patterns among human cerebellar neuron types.bioRxiv : the preprint server for biology · 2025
    Article
  11. Axonal pathology differentially affects human Purkinje cell subpopulations in the essential tremor cerebellum.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  12. Article
  13. Article
  14. Alterations in the NaCerebellum (London, England) · 2025
    Article
  15. Cerebellar control of targeted tongue movements.The Journal of physiology · 2025
    Article
  16. Article
  17. Article
  18. Review
  19. Transcriptomic gradients of the human cerebellum.Imaging neuroscience (Cambridge, Mass.) · 2025
    Article
  20. Review

119 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Nadia L CerminaraSchool of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.
Eric J LangDepartment of Neuroscience and Physiology, New York University School of Medicine, New York, New York 10016, USA.
Roy V SillitoeDepartment of Pathology &Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.
Richard AppsSchool of Physiology and Pharmacology, University of Bristol, Bristol, BS8 1TD, UK.

Funding

Steps towards a paternal gene activation therapy for Angelman syndromeU54HD083092 · NICHD · BAYLOR COLLEGE OF MEDICINE · PI LEE, BRENDAN, NELSON, DAVID LOREN · 2014 to 2019
$7.8M
SYNAPTIC ORIGINS OF CEREBELLAR DISEASER01NS089664 · NINDS · BAYLOR COLLEGE OF MEDICINE · PI SILLITOE, ROY VINCENT · 2014 to 2018
$1.7M
Medical Research Council G1100626NICHD NIH HHS 1U54HD083092-01NICHD NIH HHS U54 HD083092NINDS NIH HHS 1R01NS089664-01NINDS NIH HHS R01 NS089664
6 · The paper itself

Abstract

The adult mammalian cerebellar cortex is generally assumed to have a uniform cytoarchitecture. Differences in cerebellar function are thought to arise primarily through distinct patterns of input and output connectivity rather than as a result of variations in cortical microcircuitry. However, evidence from anatomical, physiological and genetic studies is increasingly challenging this orthodoxy, and there are now various lines of evidence indicating that the cerebellar cortex is not uniform. Here, we develop the hypothesis that regional differences in properties of cerebellar cortical microcircuits lead to important differences in information processing.

Indexed as

AnimalsCerebellar CortexHumansNerve NetPurkinje CellsSynapses

Identifiers

PMID25601779
PMCPMC4476393

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.