Evidence map›Paper›PMID 25601728›Full record

ArticleEnvironmental research2015

Associations between prenatal traffic-related air pollution exposure and birth weight: Modification by sex and maternal pre-pregnancy body mass index.

Ashwini Lakshmanan, Yueh-Hsiu Mathilda Chiu, Brent A Coull, Allan C Just, Sarah L Maxwell, Joel Schwartz, Alexandros Gryparis, Itai Kloog, Rosalind J Wright, Robert O Wright

Open access · greenAbstract read
In one paragraph

Article in Environmental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
54citing papers in PubMed, 1 pooled it
6.4field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

54 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.

  1. Pooled it
  2. Multi-Tree Model for Precision Environmental Health with Longitudinally Assessed Mixture Exposure.Journal of the Royal Statistical Society. Series C, Applied statistics · 2026
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  4. Distributed lag interaction model with index modification.Biostatistics (Oxford, England) · 2025
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  17. In-utero personal exposure to PMEnvironmental advances · 2022
    Article
  18. Article
  19. PMEnvironmental research · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Ashwini Lakshmanan *Division of Neonatal Medicine, Children's Hospital Los Angeles, Los Angeles, CA, USA.
Yueh-Hsiu Mathilda Chiu *Department of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Brent A CoullDepartment of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
Allan C JustDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
Sarah L MaxwellChanning Laboratory, Department of Medicine, Brigham and Women's Hospital & Harvard Medical School, Boston, MA.
Joel SchwartzDepartment of Environmental Health, Harvard School of Public Health, Boston, MA, USA.
Alexandros GryparisDepartment of Hygiene, Epidemiology and Medical Statistics, Medical School of Athens, Athens, Greece.
Itai KloogDepartment of Geography and Environmental Development, Ben-Gurion University of the Negev, Beersheba, Israel.
Rosalind J WrightDepartment of Pediatrics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Robert O WrightDepartment of Preventive Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Harvard University · USIcahn School of Medicine at Mount Sinai · USBen-Gurion University of the Negev · ILChild Health and Development Institute · USChildren's Hospital of Los Angeles · US

Funding

Translational Research Support CoreP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI JAIME ELIZABETH HART · 1985 to 2026
$44.6M
The Mount Sinai Transdisciplinary Center on Early Environmental ExposuresP30ES023515 · NIEHS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Manish Arora · 2014 to 2026
$21.3M
Stress, Environment, and Genetics in Urban AsthmaR01HL080674 · NHLBI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI WRIGHT, ROSALIND J · 2005 to 2014
$7.0M
MULTI-LEVEL ANALYSIS OF URBAN CHILDHOOD ASTHMA RISKR01ES010932 · NIEHS · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROSALIND J · 2000 to 2004
$3.0M
Asthma Coalition on Community, Environment and StressU01HL072494 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WRIGHT, ROSALIND J · 2002 to 2003
$1.5M
NHLBI NIH HHS R01 HL080674NHLBI NIH HHS R01HL080674NHLBI NIH HHS U01 HL072494NHLBI NIH HHS U01HL072494NIEHS NIH HHS P30 ES000002NIEHS NIH HHS P30ES000002NIEHS NIH HHS P30 ES023515NIEHS NIH HHS R01 ES010932NIEHS NIH HHS R01ES010932
6 · The paper itself

Abstract

backgroundPrenatal traffic-related air pollution exposure is linked to adverse birth outcomes. However, modifying effects of maternal body mass index (BMI) and infant sex remain virtually unexplored.

objectivesWe examined whether associations between prenatal air pollution and birth weight differed by sex and maternal BMI in 670 urban ethnically mixed mother-child pairs.

methodsBlack carbon (BC) levels were estimated using a validated spatio-temporal land-use regression (LUR) model; fine particulate matter (PM2.5) was estimated using a hybrid LUR model incorporating satellite-derived Aerosol Optical Depth measures. Using stratified multivariable-adjusted regression analyses, we examined whether associations between prenatal air pollution and calculated birth weight for gestational age (BWGA) z-scores varied by sex and maternal pre-pregnancy BMI.

resultsMedian birth weight was 3.3±0.6kg; 33% of mothers were obese (BMI ≥30kg/m(3)). In stratified analyses, the association between higher PM2.5 and lower birth weight was significant in males of obese mothers (-0.42 unit of BWGA z-score change per IQR increase in PM2.5, 95%CI: -0.79 to -0.06) ( PM2.5×sex×obesity Pinteraction=0.02). Results were similar for BC models (Pinteraction=0.002).

conclusionsAssociations of prenatal exposure to traffic-related air pollution and reduced birth weight were most evident in males born to obese mothers.

Indexed as

Maternal ExposureAdolescentAdultAir PollutantsBirth WeightBody Mass IndexBostonEnvironmental MonitoringFemaleHumansInfant, NewbornMaleMultivariate AnalysisParticulate MatterPregnancyPregnancy OutcomeAir PollutantsParticulate MatterSootVehicle EmissionsBirth weightBody mass indexPrenatal exposureSexTraffic-related air pollution

Identifiers

PMID25601728
PMCPMC4354711
OpenAlexW2070314974

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.