Evidence map›Paper›PMID 25601274›Full record

ArticleImmunology and cell biology2015

HPV16 E7 expression in skin induces TSLP secretion, type 2 ILC infiltration and atopic dermatitis-like lesions.

Anne-Sophie Bergot, Nastasia Monnet, Son Le Tran, Deepak Mittal, Jane Al-Kouba, Raymond J Steptoe, Michele A Grimbaldeston, Ian H Frazer, James W Wells

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Immunology and cell biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
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  5. Review
  6. Article
  7. Review
  8. Article
  9. The Role of IL-33/ST2 Pathway in Tumorigenesis.International journal of molecular sciences · 2018
    Review
  10. Article
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Anne-Sophie BergotThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Nastasia MonnetThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Son Le TranThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Deepak MittalThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Jane Al-KoubaThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Raymond J SteptoeThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Michele A GrimbaldestonDivision of Human Immunology, Centre for Cancer Biology, University of South Australia and SA Pathology, Adelaide, SA, Australia.
Ian H FrazerThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
James W WellsThe University of Queensland Diamantina Institute, The University of Queensland, Translational Research Institute, Brisbane, QLD, Australia.
Translational Research Institute · AUUniversity of Queensland · AUCentre for Cancer Biology · AU

Funding

Novel Interventions Against HPV-associated NeoplasiaU01CA141583 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI LAMBERT, PAUL F., MUNGER, KARL · 2009 to 2013
$3.8M
NCI NIH HHS 5U01CA141583NCI NIH HHS U01 CA141583
6 · The paper itself

Abstract

Atopic dermatitis is a common pruritic and inflammatory skin disorder with unknown etiology. Most commonly occurring during early childhood, atopic dermatitis is associated with eczematous lesions and lichenification, in which the epidermis becomes hypertrophied resulting in thickening of the skin. In this study, we report an atopic dermatitis-like pathophysiology results in a murine model following the expression of the high-risk human papillomavirus (HPV) 16 oncoprotein E7 in keratinocytes under the keratin 14 promoter. We show that HPV16 E7 expression in the skin is associated with skin thickening, acanthosis and light spongiosis. Locally, HPV16 E7-expressing skin secreted high levels of thymic stromal lymphopoietin (TSLP) and contained increased numbers of innate lymphoid cells (ILCs). High levels of circulating immunoglobulin E were associated with increased susceptibility to skin allergy in a model of cutaneous challenge, and to airway bronchiolar inflammation, enhanced airway goblet cell metaplasia and mucus production in a model of atopic march. Surprisingly, skin pathology occurred independently of T cells and mast cells. Thus, our findings suggest that the expression of a single HPV oncogene in the skin can drive the onset of atopic dermatitis-like pathology through the induction of TSLP and type 2 ILC infiltration.

Indexed as

Gene ExpressionAnimalsCytokinesDermatitis, AtopicDisease Models, AnimalImmunity, InnateInterleukin-33InterleukinsMast CellsMiceMice, TransgenicPapillomavirus E7 ProteinsPhenotypeSkinThymic Stromal LymphopoietinT-Lymphocyte SubsetsCytokinesIl33 protein, mouseInterleukin-33InterleukinsMydgf protein, mouseoncogene protein E7, Human papillomavirus type 16Papillomavirus E7 ProteinsThymic Stromal LymphopoietinTSLP protein, mouse

Identifiers

PMID25601274
PMCPMC4496302
OpenAlexW1983271455

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.