ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2015
Stress and Drug Dependence Differentially Modulate Norepinephrine Signaling in Animals with Varied HPA Axis Function.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed.
- Social isolation during adolescence alters novel object recognition memory, brain and gut gene expression, and microbiota composition in a sex-specific manner.Brain, behavior, & immunity - health · 2026Article
- Social Isolation Induces Sex-Specific Differences in Behavior and Gut Microbiota Composition in Stress-Sensitive Rats.Brain and behavior · 2025Article
- Social isolation during pregnancy disrupts maternal behavior and hippocampal neurochemistry in rats: A role for BDNF, corticosterone, and GABAARα1.Comprehensive psychoneuroendocrinology · 2025Article
- Research progress on the neural circuits mechanisms of anxiety.Frontiers in neural circuits · 2025Review
- Monoamine Transporters in Drugs of Abuse: Insights from Fast Scan Cyclic Voltammetry.Advances in neurobiology · 2025Review
- Regulation of cocaine seeking behavior by locus coeruleus noradrenergic activity in the ventral tegmental area is time- and contingency-dependent.Frontiers in neuroscience · 2022Article
- Corticotropin releasing factor and norepinephrine related circuitry changes in the bed nucleus of the stria terminalis in stress and alcohol and substance use disorders.Neuropharmacology · 2021Review
- Stress Alters the Effect of Alcohol on Catecholamine Dynamics in the Basolateral Amygdala.Frontiers in behavioral neuroscience · 2021Article
- Stress-Induced Alterations of Norepinephrine Release in the Bed Nucleus of the Stria Terminalis of Mice.ACS chemical neuroscience · 2019Article
- Stress Induced Hormone and Neuromodulator Changes in Menopausal Depressive Rats.Frontiers in psychiatry · 2018Article
- Altered Behavior in Mice Socially Isolated During Adolescence Corresponds With Immature Dendritic Spine Morphology and Impaired Plasticity in the Prefrontal Cortex.Frontiers in behavioral neuroscience · 2018Article
- Stress Induced Neuroplasticity and Mental Disorders 2018.Neural plasticity · 2018Article
- Hitchhiker's Guide to Voltammetry: Acute and Chronic Electrodes for in Vivo Fast-Scan Cyclic Voltammetry.ACS chemical neuroscience · 2017Review
- Reciprocal Catecholamine Changes during Opiate Exposure and Withdrawal.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- Contrasting Regulation of Catecholamine Neurotransmission in the Behaving Brain: Pharmacological Insights from an Electrochemical Perspective.Pharmacological reviews · 2017Review
- Medullary Norepinephrine Projections Release Norepinephrine into the Contralateral Bed Nucleus of the Stria Terminalis.ACS chemical neuroscience · 2016Article
- VTA dopamine neuron plasticity - the unusual suspects.The European journal of neuroscience · 2016Review
- Adrenergic stimulation sensitizes TRPV1 through upregulation of cystathionine β-synthetase in a rat model of visceral hypersensitivity.Scientific reports · 2015Article
- Antidepressant-like effects of guanfacine and sex-specific differences in effects on c-fos immunoreactivity and paired-pulse ratio in male and female mice.Psychopharmacology · 2015Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Previous work has demonstrated the importance of genetic factors and stress-sensitive circuits in the development of affective disorders. Anxiety and numerous psychological disorders are comorbid with substance abuse, and noradrenergic signaling in the bed nucleus of the stria terminalis (BNST) is thought to be a source of this convergence. Here, we examined the effects of different stressors on behavior and norepinephrine dynamics in the BNST of rat strains known to differ in their HPA-axis function. We compared the effects of acute morphine dependence and social isolation in non-anxious Sprague Dawley (SD) rats, and a depression model, Wistar-Kyoto (WKY) rats. We found a shared phenotype in drug-dependent and singly housed SD rats, characterized by slowed norepinephrine clearance, decreased autoreceptor function, and elevated anxiety. WKY rats exhibited changes in anxiety and autoreceptor function only following morphine dependence. To ascertain the influence of LC inhibition on this plasticity, we administered the LC-terminal-selective toxin DSP-4 to SD and WKY rats. DSP-4-treated SD rats demonstrated a dependence-like phenotype, whereas WKY rats were unchanged. Overall, our findings suggest that individuals with varying stress susceptibilities have different noradrenergic signaling changes in response to stress. These changes may establish conditions that favor stress-induced reinstatement and increase the risk for addiction.
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