ArticleMolecular oncology2015
Gene expression profiling of lobular carcinoma in situ reveals candidate precursor genes for invasion.
Article in Molecular oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- Systematic review and feasibility study on pre-analytical factors and genomic analyses on archival formalin-fixed paraffin-embedded breast cancer tissue.Scientific reports · 2024Pooled it
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- MSMP promotes an aberrant phenotype of fibroblast-like synoviocytes in rheumatoid arthritis by blocking autophagy via the RUNX1/GPR137B axis.Arthritis research & therapy · 2026Article
- Exploring glioma heterogeneity through omics networks: from gene network discovery to causal insights and patient stratification.BioData mining · 2024Article
- Pan-cancer analysis on the role of PIK3R1 and PIK3R2 in human tumors.Scientific reports · 2022Article
- Lobular Breast Cancer: Histomorphology and Different Concepts of a Special Spectrum of Tumors.Cancers · 2021Review
- American Registry of Pathology Expert Opinions: The Spectrum of Lobular Carcinoma in Situ: Diagnostic Features and Clinical Implications.Annals of diagnostic pathology · 2020Review
- Quantitative expression of MMPs 2, 9, 14, and collagen IV in LCIS and paired normal breast tissue.Scientific reports · 2019Article
- Genetic, epigenetic and transcriptional comparison of esophagus tumor‑associated and adjacent normal myofibroblasts.Oncology reports · 2019Article
- Overexpression of PIK3R1 promotes hepatocellular carcinoma progression.Biological research · 2018Article
- PIK3CA mutations are common in lobular carcinoma in situ, but are not a biomarker of progression.Breast cancer research : BCR · 2017Article
- Article
- Lobular Carcinoma in Situ: A 29-Year Longitudinal Experience Evaluating Clinicopathologic Features and Breast Cancer Risk.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2015Article
- Molecular drivers of lobular carcinoma in situ.Breast cancer research : BCR · 2015Review
- Gene expression profiling of lobular carcinoma in situ reveals candidate precursor genes for invasion.Molecular oncology · 2015Article
- Research on the mechanisms of taraxerol for the treatment of gastric cancer effect based on network pharmacology.International journal of immunopathology and pharmacologyArticle
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeLobular carcinoma in situ (LCIS) is both a risk indicator and non-obligate precursor of invasive lobular carcinoma (ILC). We sought to characterize the transcriptomic features of LCIS and ILC, with a focus on the identification of intrinsic molecular subtypes of LCIS and the changes involved in the progression from normal breast epithelium to LCIS and ILC.
methodsFresh-frozen classic LCIS, classic ILC, and normal breast epithelium (N) from women undergoing prophylactic or therapeutic mastectomy were prospectively collected, laser-capture microdissected, and subjected to gene expression profiling using Affymetrix HG-U133A 2.0 microarrays.
resultsUnsupervised hierarchical clustering of 40 LCIS samples identified 2 clusters of LCIS distinguished by 6431 probe sets (p < 0.001). Genes identifying the clusters included proliferation genes and other genes related to cancer canonical pathways such as TGF beta signaling, p53 signaling, actin cytoskeleton, apoptosis and Wnt-Signaling pathway. A supervised analysis to identify differentially expressed genes (p < 0.001) between normal epithelium, LCIS, and ILC, using 23 patient-matched triplets of N, LCIS, and ILC, identified 169 candidate precursor genes, which likely play a role in LCIS progression, including PIK3R1, GOLM1, and GPR137B. These potential precursor genes map significantly more frequently to 1q and 16q, regions frequently targeted by gene copy number alterations in LCIS and ILC.
conclusionHere we demonstrate that classic LCIS is a heterogeneous disease at the transcriptomic level and identify potential precursor genes in lobular carcinogenesis. Understanding the molecular heterogeneity of LCIS and the potential role of these potential precursor genes may help personalize the therapy of patients with LCIS.
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