Evidence map›Paper›PMID 25601173›Full record

ArticleJournal of stroke and cerebrovascular diseases : the official journal of National Stroke Association2015

A simple prediction score for developing a hospital-acquired infection after acute ischemic stroke.

Adam J Friedant, Brittany M Gouse, Amelia K Boehme, James E Siegler, Karen C Albright, Dominique J Monlezun, Alexander J George, Timothy Mark Beasley, Sheryl Martin-Schild

Open access · greenAbstract read
In one paragraph

Article in Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

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  7. Graph convolutional network-based fusion model to predict risk of hospital acquired infections.Journal of the American Medical Informatics Association : JAMIA · 2023
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  13. Observational
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  16. Risk Factors for Stroke Associated Pneumonia.Open access Macedonian journal of medical sciences · 2019
    Article
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  18. Prophylactic Antibiotic Therapy for Preventing Poststroke Infection.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2016
    Review
  19. Sex-Related Differences in the Risk of Hospital-Acquired Sepsis and Pneumonia Post Acute Ischemic Stroke.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2016
    Article
  20. Impact of Infection on Stroke Morbidity and Outcomes.Current neurology and neuroscience reports · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Adam J FriedantStroke Program, Department of Neurology, Tulane University Hospital, New Orleans, LA.
Brittany M GouseStroke Program, Department of Neurology, Tulane University Hospital, New Orleans, LA.
Amelia K BoehmeGertrude H. Sergievsky Center, Department of Neurology, Columbia University, New York, NY; Department of Neurology, School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
James E SieglerStroke Program, Department of Neurology, Hospital of the University of Pennsylvania, Philadelphia, PA.
Karen C AlbrightDepartment of Epidemiology, School of Public Health; Health Services and Outcomes Research Center for Outcome and Effectiveness Research and Education (COERE), Division of Preventive Medicine; Center of Excellence in Comparative Effectiveness Research for Eliminating Disparities (CERED) Minority Health & Health Disparities Research Center (MHRC).
Dominique J MonlezunStroke Program, Department of Neurology, Tulane University Hospital, New Orleans, LA.
Alexander J GeorgeStroke Program, Department of Neurology, Tulane University Hospital, New Orleans, LA.
Timothy Mark BeasleySection on Statistical Genetics, Department of Biostatistics, School of Public Health, University of Alabama at Birmingham, Birmingham, AL.
Sheryl Martin-SchildStroke Program, Department of Neurology, Tulane University Hospital, New Orleans, LA. Electronic address: smartin2@tulane.edu.
Tulane University · USUniversity of Alabama at Birmingham · USHospital of the University of Pennsylvania · USOffice of Minority Health · US

Funding

UAB Health Services Research (HSR) Training ProgramT32HS013852 · AHRQ · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LEVITAN, EMILY B, MUGAVERO, MICHAEL J · 2003 to 2024
$8.0M
NEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M
AHRQ HHS T32 HS013852NINDS NIH HHS NINDS NIH T32 NS007153-31NINDS NIH HHS T32 NS007153
6 · The paper itself

Abstract

backgroundHospital-acquired infections (HAIs) are a major cause of morbidity and mortality in acute ischemic stroke patients. Although prior scoring systems have been developed to predict pneumonia in ischemic stroke patients, these scores were not designed to predict other infections. We sought to develop a simple scoring system for any HAI.

methodsPatients admitted to our stroke center (July 2008-June 2012) were retrospectively assessed. Patients were excluded if they had an in-hospital stroke, unknown time from symptom onset, or delay from symptom onset to hospital arrival greater than 48 hours. Infections were diagnosed via clinical, laboratory, and imaging modalities using standard definitions. A scoring system was created to predict infections based on baseline patient characteristics.

resultsOf 568 patients, 84 (14.8%) developed an infection during their stays. Patients who developed infection were older (73 versus 64, P < .0001), more frequently diabetic (43.9% versus 29.1%, P = .0077), and had more severe strokes on admission (National Institutes of Health Stroke Scale [NIHSS] score 12 versus 5, P < .0001). Ranging from 0 to 7, the overall infection score consists of age 70 years or more (1 point), history of diabetes (1 point), and NIHSS score (0-4 conferred 0 points, 5-15 conferred 3 points, >15 conferred 5 points). Patients with an infection score of 4 or more were at 5 times greater odds of developing an infection (odds ratio, 5.67; 95% confidence interval, 3.28-9.81; P < .0001).

conclusionIn our sample, clinical, laboratory, and imaging information available at admission identified patients at risk for infections during their acute hospitalizations. If validated in other populations, this score could assist providers in predicting infections after ischemic stroke.

Indexed as

Decision Support TechniquesAdultAgedAged, 80 and overArea Under CurveBrain IschemiaChi-Square DistributionComorbidityCross InfectionFemaleHumansLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds Ratioacute ischemic strokeInfectionmodelingoutcomerisk factors

Identifiers

PMID25601173
PMCPMC4359649
OpenAlexW1986275107

What OpenQuestion holds

Textmetadata
LicenceTDM
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.