ArticleGenome biology and evolution2015
Eumetazoan cryptochrome phylogeny and evolution.
Article in Genome biology and evolution, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Pooled it
- Genetic analysis of cryptochrome in insect magnetosensitivity.Frontiers in physiology · 2022Pooled it
- A Charge-Reversal Point Mutation Completely Depletes Flavin Chromophore from European Robin Cryptochrome 4a Protein.The journal of physical chemistry letters · 2026Article
- Full-Length Cryptochrome 1 in the Outer Segments of the Retinal Blue Cone Photoreceptors in Humans and Great Apes Suggests a Role Beyond Transcriptional Repression.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025Article
- Extremely low frequency magnetic field distracts zebrafish from a visual cognitive task.Scientific reports · 2025Article
- Magnetic orientation in juvenile Atlantic herring (Journal of the Royal Society, Interface · 2024Article
- Adaptive evolution and loss of a putative magnetoreceptor in passerines.Proceedings. Biological sciences · 2024Article
- Contribution of cryptochromes and photolyases for insect life under sunlight.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2023Article
- RNA sequencing indicates widespread conservation of circadian clocks in marine zooplankton.NAR genomics and bioinformatics · 2023Article
- Bioluminescence and Photoreception in Unicellular Organisms: Light-Signalling in a Bio-Communication Perspective.International journal of molecular sciences · 2021Review
- The expression, localisation and interactome of pigeon CRY2.Scientific reports · 2021Article
- Article
- Cryptochrome expression in avian UV cones: revisiting the role of CRY1 as magnetoreceptor.Scientific reports · 2021Article
- Cryptochromes in Mammals and Birds: Clock or Magnetic Compass?Physiology (Bethesda, Md.) · 2021Article
- Biological Effects of Space Hypomagnetic Environment on Circadian Rhythm.Frontiers in physiology · 2021Review
- Newly identified Gon4l/Udu-interacting proteins implicate novel functions.Scientific reports · 2020Article
- Diversity of Light Sensing Molecules and Their Expression During the Embryogenesis of the Cuttlefish (Frontiers in physiology · 2020Article
- Expression patterns of cryptochrome genes in avian retina suggest involvement of Cry4 in light-dependent magnetoreception.Journal of the Royal Society, Interface · 2018Article
- The planarianThe Journal of experimental biology · 2017Article
- Radical-pair-based magnetoreception in birds: radio-frequency experiments and the role of cryptochrome.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cryptochromes (Crys) are light sensing receptors that are present in all eukaryotes. They mainly absorb light in the UV/blue spectrum. The extant Crys consist of two subfamilies, which are descendants of photolyases but are now involved in the regulation of circadian rhythms. So far, knowledge about the evolution, phylogeny, and expression of cry genes is still scarce. The inclusion of cry sequences from a wide range of bilaterian species allowed us to analyze their phylogeny in detail, identifying six major Cry subgroups. Selective gene inactivations and stabilizations in multiple chordate as well as arthropod lineages suggest several sub- and/or neofunctionalization events. An expression study performed in zebrafish, the model organism harboring the largest amount of crys, showed indeed only partially overlapping expression of paralogous mRNA, supporting gene sub- and/or neofunctionalization. Moreover, the daily cry expression in the adult zebrafish retina indicated varying oscillation patterns in different cell types. Our extensive phylogenetic analysis provides for the first time an overview of cry evolutionary history. Although several, especially parasitic or blind species, have lost all cry genes, crustaceans have retained up to three crys, teleosts possess up to seven, and tetrapods up to four crys. The broad and cyclic expression pattern of all cry transcripts in zebrafish retinal layers implies an involvement in retinal circadian processes and supports the hypothesis of several autonomous circadian clocks present in the vertebrate retina.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.