ArticleCritical care (London, England)2014
Three-year risk of cardiovascular disease among intensive care patients with acute kidney injury: a population-based cohort study.
Article in Critical care (London, England), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 4 of them syntheses that pooled it.
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Who cites it
51 citing papers in PubMed, 4 syntheses or guidelines pooled it, 84 citations in OpenAlex.
- Clinical prediction models in cardiac surgery-associated acute kidney injury: a systematic review and meta-analysis.Critical care (London, England) · 2026Pooled it
- The prognostic importance of duration of AKI: a systematic review and meta-analysis.BMC nephrology · 2018Pooled it
- AKI and Long-Term Risk for Cardiovascular Events and Mortality.Journal of the American Society of Nephrology : JASN · 2017Pooled it
- Health-related quality-of-life among survivors of acute kidney injury in the intensive care unit: a systematic review.Intensive care medicine · 2016Pooled it
- Predictive factors for severe long-term chronic kidney disease after acute kidney injury requiring renal replacement therapy in critically ill patients: an ancillary study of the ELVIS randomized controlled trial.Critical care (London, England) · 2022Trial
- Long-term risks of major adverse cardiovascular events after acute kidney injury: a systematic review and meta-analysis.Clinical kidney journal · 2026Article
- Acute kidney injury disrupts cardiac remodeling via SerpinA3N.bioRxiv : the preprint server for biology · 2025Article
- Epidemiology and long-term outcomes of critically ill patients with severe AKI in India and Southeast Asia.Intensive care medicine · 2025Article
- A nomogram to predict congestive heart failure in patients with acute kidney injury: a retrospective study based on the MIMIC-III database.BMC cardiovascular disorders · 2025Article
- Endothelial-specific deletion of connexin 43 improves renal function and structure after acute kidney injury.Molecular medicine (Cambridge, Mass.) · 2024Article
- The Role of Oxidative Stress as a Mechanism in the Pathogenesis of Acute Heart Failure in Acute Kidney Injury.Diagnostics (Basel, Switzerland) · 2024Review
- Acute Kidney Injury Duration and 20-Year Risks of CKD and Cardiovascular Disease.Kidney international reports · 2024Article
- Interorgan communication networks in the kidney-lung axis.Nature reviews. Nephrology · 2024Review
- Article
- The duration of acute kidney injury is an additional parameter to predict 1-year survival in very elderly patients.Journal of intensive medicine · 2023Article
- The attributable mortality of new-onset acute kidney injury among critically ill patients: a propensity-matched analysis based on a multicentre prospective cohort study.International urology and nephrology · 2022Article
- Prediction model of renal function recovery for primary membranous nephropathy with acute kidney injury.BMC nephrology · 2022Article
- The relationships of acute kidney injury duration and severity with long-term functional deterioration following partial nephrectomy.International urology and nephrology · 2022Article
- Urinary Trace Elements Are Biomarkers for Early Detection of Acute Kidney Injury.Kidney international reports · 2022Article
- Experimental models of acute kidney injury for translational research.Nature reviews. Nephrology · 2022Review
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
introductionAcute kidney injury (AKI) is common among intensive care unit (ICU) patients, but follow-up data on subsequent risk of cardiovascular disease remain sparse. We examined the impact of AKI on three-year risk of first-time heart failure, myocardial infarction (MI), and stroke among ICU patients surviving to hospital discharge, and whether this risk is modified by renal recovery before hospital discharge.
methodsWe used population-based medical registries to identify all adult patients admitted to an ICU in Northern Denmark between 2005 and 2010 who survived to hospital discharge and who had no previous or concurrent diagnosis of heart failure, MI, or stroke. AKI was defined according to the creatinine criteria in the Kidney Disease Improving Global Outcomes classification. We computed the three-year cumulative risk of hospitalization with heart failure, MI, and stroke for patients with and without AKI and the hazard ratios (HRs), using a Cox model adjusted for potential confounders.
resultsAmong 21,556 ICU patients surviving to hospital discharge, 4,792 (22.2%) had an AKI episode. Three-year cumulative risk of heart failure was 2.2% in patients without AKI, 5.0% for AKI stage 1, and 5.0% for stages 2 to 3. The corresponding adjusted HRs were 1.33 (95% confidence interval (CI), 1.06 to 1.66) for patients with AKI stage 1 and 1.45 (95% CI, 1.14 to 1.84) for AKI stages 2 to 3, compared to patients without AKI. The three-year cumulative MI risk was 1.0% for patients without AKI, 1.8% for patients with AKI stage 1 and 2.3% for patients with AKI stages 2 to 3. The adjusted HR for MI was 1.04 (95% CI, 0.71 to 1.51) for patients with AKI stage 1 and 1.51 (95% CI, 1.05 to 2.18) for patients with AKI stages 2 to 3, compared with patients without AKI. We found no association between AKI and stroke. The increased risk of heart failure and MI persisted in patients with renal recovery before discharge, although it was less pronounced than in patients without renal recovery.
conclusionsICU patients surviving any stage of AKI are at increased three-year risk of heart failure, but not stroke. Only AKI stages 2 to 3 are associated with increased MI risk.
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