Evidence map›Paper›PMID 25600597›Full record

ArticleJournal of clinical virology : the official publication of the Pan American Society for Clinical Virology2015

Hepatitis B virus infection in post-vaccination South Africa: occult HBV infection and circulating surface gene variants.

Edina Amponsah-Dacosta, Ramokone L Lebelo, J Nare Rakgole, Selokela G Selabe, Maemu P Gededzha, Simnikiwe H Mayaphi, Eleanor A Powell, Jason T Blackard, M Jeffrey Mphahlele

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 3 pooled it
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 35 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Edina Amponsah-DacostaHIV and Hepatitis Research Unit, Department of Virology, University of Limpopo (Medunsa Campus) and National Health Laboratory Service, Pretoria, South Africa.
Ramokone L LebeloHIV and Hepatitis Research Unit, Department of Virology, University of Limpopo (Medunsa Campus) and National Health Laboratory Service, Pretoria, South Africa.
J Nare RakgoleHIV and Hepatitis Research Unit, Department of Virology, University of Limpopo (Medunsa Campus) and National Health Laboratory Service, Pretoria, South Africa.
Selokela G SelabeHIV and Hepatitis Research Unit, Department of Virology, University of Limpopo (Medunsa Campus) and National Health Laboratory Service, Pretoria, South Africa.
Maemu P GededzhaHIV and Hepatitis Research Unit, Department of Virology, University of Limpopo (Medunsa Campus) and National Health Laboratory Service, Pretoria, South Africa.
Simnikiwe H MayaphiDepartment of Medical Virology, University of Pretoria/Tshwane Academic Division of NHLS, Pretoria, South Africa.
Eleanor A PowellDivision of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
Jason T BlackardDivision of Digestive Diseases, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USA.
M Jeffrey MphahleleHIV and Hepatitis Research Unit, Department of Virology, University of Limpopo (Medunsa Campus) and National Health Laboratory Service, Pretoria, South Africa. Electronic address: jeffrey.mphahlele@mrc.ac.za.
National Health Laboratory Service · ZAUniversity of Cincinnati Medical Center · USUniversity of Limpopo · ZAUniversity of Pretoria · ZA

Funding

Occult Hepatitis B Infection in South African HIV PatientsR21AI096958 · NIAID · UNIVERSITY OF CINCINNATI · PI BLACKARD, JASON T · 2011 to 2012
$412k
NIAID NIH HHS R21 AI096958
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe aim of this study was to investigate the prevalence of occult hepatitis B virus (HBV) infection and the HBV surface (S) gene variants circulating in the South African population after nearly two decades of universal hepatitis B vaccination. STUDY

designFrom a previous serosurvey, 201 serum samples with serological evidence of exposure to HBV were identified and these were stratified into post- and pre-vaccine introduction populations. For all samples, HBV DNA was screened and quantified using a real-time PCR assay and results analysed together with HBV serological markers. Where HIV results were available, subset analysis was performed. The HBV S gene was PCR-amplified and sequences analysed for a total of 37 isolates.

resultsThe prevalence of occult HBV infection reduced from 70.4% in the pre-vaccine introduction era to 66.0% post-vaccine introduction. There was an association between HIV infection and an increase in prevalence of occult HBV infection within the post-vaccine introduction population, although this was not statistically significant. Furthermore, sequence analysis revealed the following HBV subgenotypes; A1 (n=34), A2 (n=2) and a rare D4 isolate. HBV S gene variants, including diagnostic escape mutants were isolated.

conclusionThere was a decline in the prevalence of occult HBV infection in post-vaccination South Africa, although the disease burden remains significant in the HIV co-infected population. After nearly two decades of a universal hepatitis B vaccination programme, no positive selection of vaccine escape mutants were observed.

Indexed as

AdolescentAdultChildChild, PreschoolDNA, ViralFemaleHepatitis BHepatitis B Surface AntigensHepatitis B VaccinesHumansInfantMaleMutant ProteinsPrevalenceReal-Time Polymerase Chain ReactionSequence Analysis, DNADNA, ViralHepatitis B Surface AntigensHepatitis B VaccinesMutant ProteinsDiagnostic escape mutantsHepatitis B vaccineHIV infectionOccult HBV infectionSubgenotype D4

Identifiers

PMID25600597
PMCPMC4560343
OpenAlexW2006965487

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.