ArticleRadiation and environmental biophysics2015
Comparison study of in vivo dose response to laser-driven versus conventional electron beam.
Article in Radiation and environmental biophysics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 40 citations in OpenAlex.
- Preclinical tumor control with a laser-accelerated high-energy electron radiotherapy prototype.Nature communications · 2025Article
- FLASH Radiotherapy: Benefits, Mechanisms, and Obstacles to Its Clinical Application.International journal of molecular sciences · 2024Review
- The effect of laser pulse evolution on down-ramp injection in laser wakefield accelerators.Scientific reports · 2024Article
- Anesthetic Oxygen Use and Sex Are Critical Factors in the FLASH Sparing Effect.Advances in radiation oncology · 2024Article
- Anesthetic oxygen use and sex are critical factors in the FLASH sparing effect.bioRxiv : the preprint server for biology · 2023Article
- Transformative Technology for FLASH Radiation Therapy.Applied sciences (Basel, Switzerland) · 2023Article
- Ultra-high dose rate electron beams and the FLASH effect: From preclinical evidence to a new radiotherapy paradigm.Medical physics · 2022Review
- Back to the Future: Very High-Energy Electrons (VHEEs) and Their Potential Application in Radiation Therapy.Cancers · 2021Review
- Spectral and spatial shaping of laser-driven proton beams using a pulsed high-field magnet beamline.Scientific reports · 2020Article
- A proof of principle experiment for microbeam radiation therapy at the Munich compact light source.Radiation and environmental biophysics · 2020Article
- Laser-Driven Ultrashort Pulsed Electron Beam Radiation at Doses of 0.5 and 1.0 Gy Induces Apoptosis in Human Fibroblasts.International journal of molecular sciences · 2019Article
- Laser-driven radiation: Biomarkers for molecular imaging of high dose-rate effects.Medical physics · 2019Review
- Analysing Tumour Growth Delay Data from Animal Irradiation Experiments with Deviations from the Prescribed Dose.Cancers · 2019Article
- Ultra-High Dose Rate (FLASH) Radiotherapy: Silver Bullet or Fool's Gold?Frontiers in oncology · 2019Review
- Article
- Radiobiological influence of megavoltage electron pulses of ultra-high pulse dose rate on normal tissue cells.Radiation and environmental biophysics · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
19 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The long-term goal to integrate laser-based particle accelerators into radiotherapy clinics not only requires technological development of high-intensity lasers and new techniques for beam detection and dose delivery, but also characterization of the biological consequences of this new particle beam quality, i.e. ultra-short, ultra-intense pulses. In the present work, we describe successful in vivo experiments with laser-driven electron pulses by utilization of a small tumour model on the mouse ear for the human squamous cell carcinoma model FaDu. The already established in vitro irradiation technology at the laser system JETI was further enhanced for 3D tumour irradiation in vivo in terms of beam transport, beam monitoring, dose delivery and dosimetry in order to precisely apply a prescribed dose to each tumour in full-scale radiobiological experiments. Tumour growth delay was determined after irradiation with doses of 3 and 6 Gy by laser-accelerated electrons. Reference irradiation was performed with continuous electron beams at a clinical linear accelerator in order to both validate the dedicated dosimetry employed for laser-accelerated JETI electrons and above all review the biological results. No significant difference in radiation-induced tumour growth delay was revealed for the two investigated electron beams. These data provide evidence that the ultra-high dose rate generated by laser acceleration does not impact the biological effectiveness of the particles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.