Evidence map›Paper›PMID 25600489›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2015

Brincidofovir for polyomavirus-associated nephropathy after allogeneic hematopoietic stem cell transplantation.

Genovefa A Papanicolaou, Yeon Joo Lee, James W Young, Surya V Seshan, Adam M Boruchov, Gregory Chittick, Herve Momméja-Marin, Ilya G Glezerman

Abstract readCase Reports
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Native kidney BK virus nephropathy, a systematic review.Transplant infectious disease : an official journal of the Transplantation Society · 2019
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. BK viral infection: A review of management and treatment.World journal of transplantation · 2023
    Review
  7. Article
  8. BK Virus Nephropathy: Prevalence, Impact and Management Strategies.International journal of nephrology and renovascular disease · 2020
    Review
  9. Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Symptomatic BK Virus Infection Is Associated With Kidney Function Decline and Poor Overall Survival in Allogeneic Hematopoietic Stem Cell Recipients.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2016
    Article
  15. Review
  16. Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Genovefa A PapanicolaouInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY; Department of Medicine, Weill Cornell Medical College, New York, NY.
Yeon Joo LeeInfectious Disease Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
James W YoungDepartment of Medicine, Weill Cornell Medical College, New York, NY; Adult Bone Marrow Transplantation Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY.
Surya V SeshanDepartment of Pathology, Weill Cornell Medical College, New York, NY.
Adam M BoruchovSaint Francis Hospital and Medical Center and University of Connecticut School of Medicine, Hartford, CT.
Gregory ChittickChimerix, Inc, Durham, NC.
Herve Momméja-MarinChimerix, Inc, Durham, NC.
Ilya G GlezermanDepartment of Medicine, Weill Cornell Medical College, New York, NY; Renal Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY. Electronic address: glezermi@mskcc.org.

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Polyomavirus-associated nephropathy (PVAN) is common in patients who have undergone kidney transplantation and has been reported in hematopoietic stem cell (HSC) transplant recipients. Aside from reduction of immunosuppression, few therapeutic options exist for treatment of PVAN. We report a case of PVAN in a severely immunocompromised allogeneic HSC transplant recipient that was treated with brincidofovir without reduction of immunosuppression. We review our institutional experience of PVAN in HSC transplantation and discuss the potential use of brincidofovir for treatment.

Indexed as

BK VirusHematopoietic Stem Cell TransplantationCytomegalovirus InfectionsCytosineHumansImmunocompromised HostKidney DiseasesMaleMiddle AgedOrganophosphonatesPolyomavirusPolyomavirus InfectionsTumor Virus InfectionsViremiabrincidofovirCytosineOrganophosphonatesBK viremiaBK virusbrincidofovirhematopoietic stem cell (HSC) transplantationkidney failurePolyomavirus-associated nephropathy (PVAN)

Identifiers

PMID25600489
PMCPMC5916792

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.