Evidence map›Paper›PMID 25600222›Full record

ArticleAmerican journal of hypertension2015

Association Between Serum 25-Hydroxy Vitamin D Levels and Blood Pressure Among Adolescents in Two Resource-Limited Settings in Peru.

Katherine Tomaino, Karina M Romero, Colin L Robinson, Lauren M Baumann, Nadia N Hansel, Suzanne L Pollard, Robert H Gilman, Edward Mougey, John J Lima, William Checkley and 1 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hypertension, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Effect of vitamin D deficiency on metabolic syndrome among Korean shift workers.Scandinavian journal of work, environment & health · 2023
    Article
  3. Review
  4. Association of sun exposure and seasonality with vitamin D levels in Brazilian children and adolescents.Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo · 2023
    Article
  5. Observational
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Vitamin D and Cardiovascular Risk in Children.Chinese medical journal · 2017
    Review
  12. Review
  13. Article
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Katherine TomainoDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA;
Karina M RomeroBiomedical Research Unit, A.B. PRISMA, Lima, Peru;
Colin L RobinsonDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA;
Lauren M BaumannDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA;
Nadia N HanselDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA;
Suzanne L PollardProgram in Global Disease Epidemiology and Control, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA;
Robert H GilmanProgram in Global Disease Epidemiology and Control, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA;
Edward MougeyCenter for Pharmacogenomics and Translational Research, Nemours Children Clinic, Jacksonville, Florida, USA.
John J LimaCenter for Pharmacogenomics and Translational Research, Nemours Children Clinic, Jacksonville, Florida, USA.
William CheckleyDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA; Program in Global Disease Epidemiology and Control, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, Maryland, USA; wcheckl1@jhmi.edu.
PURA study investigators
Johns Hopkins University · USPrisma · PE

Funding

Fogarty International Clinical Research Scholars Support Center @ Vanderbilt-AAMCR24TW007988 · FIC · VANDERBILT UNIVERSITY · PI VERMUND, STEN H. · 2007 to 2011
$27.6M
Genetic Susceptibility to Asthma and IndoorAir Pollution in PeruR01ES018845 · NIEHS · JOHNS HOPKINS UNIVERSITY · PI HANSEL, NADIA N · 2010 to 2014
$3.8M
Acute Lung Injury: Application of Novel Approaches to Longitudinal Data AnalysisR00HL096955 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHECKLEY, WILLIAM · 2011 to 2013
$723k
Short term training: Infectious Diseases & Tropical Diseases in PeruT35AI065385 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GILMAN, ROBERT H · 2006 to 2010
$325k
FIC NIH HHS R24 TW007988Medical Research Council MR/K007467/1NHLBI NIH HHS R00 HL096955NHLBI NIH HHS R00HL096955NIAID NIH HHS T35 AI065385NIAID NIH HHS T35AI065385NIEHS NIH HHS R01 ES018845NIEHS NIH HHS R01ES018845
6 · The paper itself

Abstract

introductionSerum 25-hydroxyvitamin D (25OHD) deficiency (<50 nmol/l or 20 ng/ml) has been associated with increased blood pressure (BP) in observational studies. A paucity of data on this relationship is available in Latin American or child populations. This study investigates the association between 25OHD levels and BP in adolescents at risk for vitamin D deficiency in 2 Peruvian settings.

methodsIn a population-based study of 1,441 Peruvian adolescents aged 13-15 years, 1,074 (75%) provided a serum blood sample for 25OHD analysis and BP measurements. Relationships between 25OHD and BP metrics were assessed using multiple linear regressions, adjusted for anthropometrics and sociodemographic factors.

results25OHD deficiency was associated with an elevated diastolic BP (DBP) (1.09 mm Hg increase, 95% confidence interval: 0.04 to 2.14; P = 0.04) compared to nondeficient adolescents. Systolic BP (SBP) trended to increase with vitamin D deficiency (1.30 mm Hg increase, 95% confidence interval: -0.13 to 2.72; P = 0.08). Mean arterial pressure (MAP) was also greater in adolescents with 25OHD (1.16 mm Hg increase, 95% confidence interval: 0.10 to 2.22; P = 0.03). SBP was found to demonstrate a U-shaped relationship with 25OHD, while DBP and MAP demonstrated inverse J-shaped relationships with serum 25OHD status. The association between 25OHD deficiency and BP was not different across study sites (all P ≥ 0.19). DISCUSSION: Adolescents deficient in 25OHD demonstrated increased DBP and MAP and a trend toward increased SBP, when compared to nondeficient subjects. 25OHD deficiency early in life was associated with elevated BP metrics, which may predispose risk of hypertension later in adulthood.

Indexed as

Arterial PressureAdolescentAsthmaBlood PressureCross-Sectional StudiesFemaleHealth ResourcesHumansHypertensionIncomeLinear ModelsMaleMultivariate AnalysisOverweightPeruSmoking25-hydroxyvitamin DTobacco Smoke PollutionVitamin D25OHD deficiencyadolescentsblood pressurecardiovascular diseasediastolic blood pressurehypertensionmean arterial pressuresystolic blood pressure.

Identifiers

PMID25600222
PMCPMC4580534
OpenAlexW2104522927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.