ArticleInhalation toxicology2015
Acrolein inhalation alters arterial blood gases and triggers carotid body-mediated cardiovascular responses in hypertensive rats.
Article in Inhalation toxicology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 50 citations in OpenAlex.
- Sleep disruption from inhalation of biomass smoke: a basis for coincident hypertension?Particle and fibre toxicology · 2025Article
- Volatile organic compounds exposure in relation to glucose homeostasis and type 2 diabetes in older adults from the NHANES.Scientific reports · 2024Article
- Food contamination and cardiovascular disease: a narrative review.Internal and emergency medicine · 2024Review
- Impact of Wildfires on Cardiovascular Health.Circulation research · 2024Review
- Associations between specific volatile organic chemical exposures and cardiovascular disease risks: insights from NHANES.Frontiers in public health · 2024Article
- Exposure to Volatile Organic Compounds Is Associated with Hypertension in Black Adults: The Jackson Heart Study.Environmental research · 2023Article
- E-cigarettes and their lone constituents induce cardiac arrhythmia and conduction defects in mice.Nature communications · 2022Article
- Xenobiotics Delivered by Electronic Nicotine Delivery Systems: Potential Cellular and Molecular Mechanisms on the Pathogenesis of Chronic Kidney Disease.International journal of molecular sciences · 2022Review
- RETRACTED: Effect Comparison of E-Cigarette and Traditional Smoking and Association with Stroke-A Cross-Sectional Study of NHANES.Neurology international · 2022Article
- Acrolein inhalation acutely affects the regulation of mitochondrial metabolism in rat lung.Toxicology · 2022Article
- Exposure to volatile organic compounds - acrolein, 1,3-butadiene, and crotonaldehyde - is associated with vascular dysfunction.Environmental research · 2021Article
- Biological Toxicity of the Compositions in Electronic-Cigarette on Cardiovascular System.Journal of cardiovascular translational research · 2021Review
- The Cardiovascular Effects of Electronic Cigarettes.Current cardiology reports · 2021Review
- Peat smoke inhalation alters blood pressure, baroreflex sensitivity, and cardiac arrhythmia risk in rats.Journal of toxicology and environmental health. Part A · 2020Article
- Air Pollution-Induced Autonomic Modulation.Physiology (Bethesda, Md.) · 2020Review
- Cardiac toxicity of acrolein exposure in embryonic zebrafish (Danio rerio).Environmental science and pollution research international · 2020Article
- Acrolein exerts a genotoxic effect in the Leydig cells by stimulating DNA damage-induced apoptosis.Environmental science and pollution research international · 2020Article
- Cardiovascular injury induced by tobacco products: assessment of risk factors and biomarkers of harm. A Tobacco Centers of Regulatory Science compilation.American journal of physiology. Heart and circulatory physiology · 2019Review
- Impact of Electronic Cigarettes on the Cardiovascular System.Journal of the American Heart Association · 2017Review
- Respiratory Effects and Systemic Stress Response Following Acute Acrolein Inhalation in Rats.Toxicological sciences : an official journal of the Society of Toxicology · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
contextAir pollution exposure affects autonomic function, heart rate, blood pressure and left ventricular function. While the mechanism for these effects is uncertain, several studies have reported that air pollution exposure modifies activity of the carotid body, the major organ that senses changes in arterial oxygen and carbon dioxide levels, and elicits downstream changes in autonomic control and cardiac function.
objectiveWe hypothesized that exposure to acrolein, an unsaturated aldehyde and mucosal irritant found in cigarette smoke and diesel exhaust, would activate the carotid body chemoreceptor response and lead to secondary cardiovascular responses in rats. MATERIALS AND
methodsSpontaneously hypertensive (SH) rats were exposed once for 3 h to 3 ppm acrolein gas or filtered air in whole body plethysmograph chambers. To determine if the carotid body mediated acrolein-induced cardiovascular responses, rats were pretreated with an inhibitor of cystathionine γ-lyase (CSE), an enzyme essential for carotid body signal transduction.
resultsAcrolein exposure induced several cardiovascular effects. Systolic, diastolic and mean arterial blood pressure increased during exposure, while cardiac contractility decreased 1 day after exposure. The cardiovascular effects were associated with decreases in pO2, breathing frequency and expiratory time, and increases in sympathetic tone during exposure followed by parasympathetic dominance after exposure. The CSE inhibitor prevented the cardiovascular effects of acrolein exposure. DISCUSSION AND
conclusionPretreatment with the CSE inhibitor prevented the cardiovascular effects of acrolein, suggesting that the cardiovascular responses with acrolein may be mediated by carotid body-triggered changes in autonomic tone. (This abstract does not reflect EPA policy.).
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