ArticleEMBO reports2015
Glycolytic enzymes localize to ribonucleoprotein granules in Drosophila germ cells, bind Tudor and protect from transposable elements.
Article in EMBO reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- Somatic cells compartmentalise their carbohydrate metabolism to sustain germ cell survival.The EMBO journal · 2026Article
- Multiple domains of scaffold Tudor protein play nonredundant roles inLife science alliance · 2025Article
- PIWI proteins and piRNAs: key regulators of stem cell biology.Frontiers in cell and developmental biology · 2025Review
- Dynamic protein assembly and architecture of the large solitary membraneless organelle during germline development in the wasp Nasonia vitripennis.Development (Cambridge, England) · 2024Article
- piRNAs are regulators of metabolic reprogramming in stem cells.Nature communications · 2024Article
- Looking at the Pretty "Phase" of Membraneless Organelles: A View FromFrontiers in cell and developmental biology · 2022Review
- Glial granules contain germline proteins in the Drosophila brain, which regulate brain transcriptome.Communications biology · 2020Article
- Protein components of ribonucleoprotein granules from Drosophila germ cells oligomerize and show distinct spatial organization during germline development.Scientific reports · 2019Article
- Transcriptomic and functional analysis of the oosome, a unique form of germ plasm in the wasp Nasonia vitripennis.BMC biology · 2019Article
- Article
- An unregulated regulator: Vasa expression in the development of somatic cells and in tumorigenesis.Developmental biology · 2016Review
- Germ Plasm Biogenesis--An Oskar-Centric Perspective.Current topics in developmental biology · 2016Review
- RNA-binding proteins in mouse male germline stem cells: a mammalian perspective.Cell regeneration (London, England) · 2016Article
- Coordinate post-transcriptional repression of Dpp-dependent transcription factors attenuates signal range during development.Development (Cambridge, England) · 2015Article
- Analysis of RNA Interference Lines Identifies New Functions of Maternally-Expressed Genes Involved in Embryonic Patterning in Drosophila melanogaster.G3 (Bethesda, Md.) · 2015Article
Corrections and comments
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Authors and funding
13 authors at 4 institutions in 2 countries.
Funding
Abstract
Germ cells give rise to all cell lineages in the next-generation and are responsible for the continuity of life. In a variety of organisms, germ cells and stem cells contain large ribonucleoprotein granules. Although these particles were discovered more than 100 years ago, their assembly and functions are not well understood. Here we report that glycolytic enzymes are components of these granules in Drosophila germ cells and both their mRNAs and the enzymes themselves are enriched in germ cells. We show that these enzymes are specifically required for germ cell development and that they protect their genomes from transposable elements, providing the first link between metabolism and transposon silencing. We further demonstrate that in the granules, glycolytic enzymes associate with the evolutionarily conserved Tudor protein. Our biochemical and single-particle EM structural analyses of purified Tudor show a flexible molecule and suggest a mechanism for the recruitment of glycolytic enzymes to the granules. Our data indicate that germ cells, similarly to stem cells and tumor cells, might prefer to produce energy through the glycolytic pathway, thus linking a particular metabolism to pluripotency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.