Evidence map›Paper›PMID 25600098›Full record

ReviewNature reviews. Urology2015

The microbiome of the urinary tract--a role beyond infection.

Samantha A Whiteside, Hassan Razvi, Sumit Dave, Gregor Reid, Jeremy P Burton

3 registry-linked trialsAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Urology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 325 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
325citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03987126 phase3completednot on this mapstarted 2021, after this paper: background citation

Use of Novel Human Milk Prebiotics to Improve the Quality of Life for Spinal Cord Injury Patients With Bowel and Bladder Dysfunction

TypeinterventionalSponsorLondon Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph'sRan2021 to 2023Enrolled30ConditionsSpinal Cord Injuries, Neurogenic Bowel, Bladder DysfunctionArmsHuman Milk Oligosaccharides (HMO), Placebo
NCT05318365 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Bladder and Bowel Dysfunction in Children

TypeinterventionalSponsorUniversity of AarhusRan2022 to 2025Enrolled100ConditionsBladder and Bowel DysfunctionArmsPolyethylene Glycol 3350, Urotherapy
NCT06289283 active not recruitingnot on this mapstarted 2023, after this paper: background citation

Profiling Urinary Microbiota In Male Patients With Bladder Cancer

TypeobservationalSponsorTheodor Bilharz Research InstituteRan2023 to 2026Enrolled38ConditionsUrinary Bladder Neoplasms, MicrotiaArmsUrine samples and tissue samples: Samples will be collected in clean leak-proof containers without disinfectant or detergent residue and with tight-fitting leak-proof lids and preserved in a refrigera
3 · Its place in the literature

Who cites it

325 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Metabolic changes in kidney stone disease.Frontiers in immunology · 2023
    Pooled it
  4. Pooled it
  5. Pooled it
  6. Trial
  7. Review
  8. Microbiome and chronic pelvic pain in women: a mini-review.Human reproduction (Oxford, England) · 2026
    Review
  9. Review
  10. Article
  11. Article
  12. Article
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  14. Article
  15. Review
  16. Nanopore sequencing of the Tunisian gut microbiome: effect of the DNA extraction methods.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2026
    Article
  17. Review
  18. Article
  19. Review
  20. Article

265 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Samantha A WhitesideDepartment of Microbiology and Immunology, The University of Western Ontario, 1151 Richmond Street, London, ON N6A 3K7, Canada.
Hassan RazviDivision of Urology, Department of Surgery, The University of Western Ontario, 1151 Richmond Street, London, ON N6A 3K7, Canada.
Sumit DaveDivision of Urology, Department of Surgery, The University of Western Ontario, 1151 Richmond Street, London, ON N6A 3K7, Canada.
Gregor ReidCanadian Centre for Human Microbiome and Probiotic Research, Lawson Health Research Institute, 268 Grosvenor Street, London, ON N6A 4V2, Canada.
Jeremy P BurtonDivision of Urology, Department of Surgery, The University of Western Ontario, 1151 Richmond Street, London, ON N6A 3K7, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urologists rarely need to consider bacteria beyond their role in infectious disease. However, emerging evidence shows that the microorganisms inhabiting many sites of the body, including the urinary tract--which has long been assumed sterile in healthy individuals--might have a role in maintaining urinary health. Studies of the urinary microbiota have identified remarkable differences between healthy populations and those with urologic diseases. Microorganisms at sites distal to the kidney, bladder and urethra are likely to have a profound effect on urologic health, both positive and negative, owing to their metabolic output and other contributions. Connections between the gut microbiota and renal stone formation have already been discovered. In addition, bacteria are also used in the prevention of bladder cancer recurrence. In the future, urologists will need to consider possible influences of the microbiome in diagnosis and treatment of certain urological conditions. New insights might provide an opportunity to predict the risk of developing certain urological diseases and could enable the development of innovative therapeutic strategies.

Indexed as

MicrobiotaAdjuvants, ImmunologicBCG VaccineCarcinoma, Transitional CellGastrointestinal MicrobiomeHumansUrinary Bladder NeoplasmsUrinary TractUrinary Tract InfectionsUrolithiasisAdjuvants, ImmunologicBCG Vaccine

Identifiers

PMID25600098

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.