ArticleScientific reports2015
Characterising two-pathogen competition in spatially structured environments.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Competition of SARS-CoV-2 variants on the pandemic transmission dynamics.Chaos, solitons, and fractals · 2023Article
- Analysis of the competition among viral strains using a temporal interaction-driven contagion model.Scientific reports · 2022Article
- Molecular detection of novelOpen research Africa · 2022Article
- Reconstructing contact network structure and cross-immunity patterns from multiple infection histories.PLoS computational biology · 2021Article
- The coSIR model predicts effective strategies to limit the spread of SARS-CoV-2 variants with low severity and high transmissibility.Nonlinear dynamics · 2021Article
- Interplay between competitive and cooperative interactions in a three-player pathogen system.Royal Society open science · 2020Article
- Coevolution spreading in complex networks.Physics reports · 2019Review
- Host contact dynamics shapes richness and dominance of pathogen strains.PLoS computational biology · 2019Article
- Persistent spatial patterns of interacting contagions.Physical review. E · 2019Article
- Origin and dissemination of hepatitis B virus genotype C in East Asia revealed by phylodynamic analysis and historical correlates.Journal of viral hepatitis · 2019Article
- Limited role of spatial self-structuring in emergent trade-offs during pathogen evolution.Scientific reports · 2018Article
- Human mobility networks and persistence of rapidly mutating pathogens.Royal Society open science · 2017Article
- Spatial evolutionary epidemiology of spreading epidemics.Proceedings. Biological sciences · 2016Article
Corrections and comments
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Authors and funding
6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Different pathogens spreading in the same host population often generate complex co-circulation dynamics because of the many possible interactions between the pathogens and the host immune system, the host life cycle, and the space structure of the population. Here we focus on the competition between two acute infections and we address the role of host mobility and cross-immunity in shaping possible dominance/co-dominance regimes. Host mobility is modelled as a network of traveling flows connecting nodes of a metapopulation, and the two-pathogen dynamics is simulated with a stochastic mechanistic approach. Results depict a complex scenario where, according to the relation among the epidemiological parameters of the two pathogens, mobility can either be non-influential for the competition dynamics or play a critical role in selecting the dominant pathogen. The characterisation of the parameter space can be explained in terms of the trade-off between pathogen's spreading velocity and its ability to diffuse in a sparse environment. Variations in the cross-immunity level induce a transition between presence and absence of competition. The present study disentangles the role of the relevant biological and ecological factors in the competition dynamics, and provides relevant insights into the spatial ecology of infectious diseases.
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