ArticleAngewandte Chemie (International ed. in English)2015
Electron tunneling rates in respiratory complex I are tuned for efficient energy conversion.
Article in Angewandte Chemie (International ed. in English), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 66 citations in OpenAlex.
- Impact of weak radiofrequency and static magnetic fields on key signaling molecules, intracellular pH, membrane potential, and cell growth in HT-1080 fibrosarcoma cells.Scientific reports · 2023Article
- HScientific reports · 2023Article
- From the 'black box' to 'domino effect' mechanism: what have we learned from the structures of respiratory complex I.The Biochemical journal · 2023Review
- Bioelectric Fields at the Beginnings of Life.Bioelectricity · 2022Review
- A Quinol Anion as Catalytic Intermediate Coupling Proton Translocation With Electron Transfer inFrontiers in chemistry · 2021Article
- Functional Water Wires Catalyze Long-Range Proton Pumping in the Mammalian Respiratory Complex I.Journal of the American Chemical Society · 2020Article
- Key role of quinone in the mechanism of respiratory complex I.Nature communications · 2020Article
- From sunscreens to medicines: Can a dissipation hypothesis explain the beneficial aspects of many plant compounds?Phytotherapy research : PTR · 2020Review
- Formation of Unstable and very Reactive Chemical Species Catalyzed by Metalloenzymes: A Mechanistic Overview.Molecules (Basel, Switzerland) · 2019Review
- A mechanism to prevent production of reactive oxygen species by Escherichia coli respiratory complex I.Nature communications · 2019Article
- Energetics and Dynamics of Proton-Coupled Electron Transfer in the NADH/FMN Site of Respiratory Complex I.Journal of the American Chemical Society · 2019Article
- Molecular dynamics and structural models of the cyanobacterial NDH-1 complex.Biochimica et biophysica acta. Bioenergetics · 2019Article
- How inter-subunit contacts in the membrane domain of complex I affect proton transfer energetics.Biochimica et biophysica acta. Bioenergetics · 2018Article
- Long-range proton-coupled electron transfer in biological energy conversion: towards mechanistic understanding of respiratory complex I.Journal of the Royal Society, Interface · 2018Review
- Robust Production, Crystallization, Structure Determination, and Analysis of [Fe-S] Proteins: Uncovering Control of Electron Shuttling and Gating in the Respiratory Metabolism of Molybdopterin Guanine Dinucleotide Enzymes.Methods in enzymology · 2018Article
- Terminal Electron-Proton Transfer Dynamics in the Quinone Reduction of Respiratory Complex I.Journal of the American Chemical Society · 2017Article
- Reduction of the off-pathway iron-sulphur cluster N1a of Escherichia coli respiratory complex I restrains NADScientific reports · 2017Article
- Role of water and protein dynamics in proton pumping by respiratory complex I.Scientific reports · 2017Article
- Symmetry-related proton transfer pathways in respiratory complex I.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Electron-transfer chain in respiratory complex I.Scientific reports · 2017Article
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Respiratory complex I converts the free energy of ubiquinone reduction by NADH into a proton motive force, a redox reaction catalyzed by flavin mononucleotide(FMN) and a chain of seven iron-sulfur centers. Electron transfer rates between the centers were determined by ultrafast freeze-quenching and analysis by EPR and UV/Vis spectroscopy. The complex rapidly oxidizes three NADH molecules. The electron-tunneling rate between the most distant centers in the middle of the chain depends on the redox state of center N2 at the end of the chain, and is sixfold slower when N2 is reduced. The conformational changes that accompany reduction of N2 decrease the electronic coupling of the longest electron-tunneling step. The chain of iron-sulfur centers is not just a simple electron-conducting wire; it regulates the electron-tunneling rate synchronizing it with conformation-mediated proton pumping, enabling efficient energy conversion. Synchronization of rates is a principle means of enhancing the specificity of enzymatic reactions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.