Evidence map›Paper›PMID 25599669›Full record

ArticleCurrent protocols in human genetics2015

Molecular cytogenetic analysis of telomere rearrangements.

Christa Lese Martin, David H Ledbetter

Abstract read
In one paragraph

Article in Current protocols in human genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Prenatal Diagnosis by Chromosome Microarray Analysis, An Indian Experience.Journal of obstetrics and gynaecology of India · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Christa Lese MartinAutism and Developmental Medicine Institute, Geisinger Health System, Danville, Pennsylvania.
David H LedbetterAutism and Developmental Medicine Institute, Geisinger Health System, Danville, Pennsylvania.

Funding

GENE DOSAGE IMBALANCE IN NEURODEVELOPMENTAL DISORDERSR01MH074090 · NIMH · GEISINGER CLINIC · PI David H. Ledbetter, CHRISTA LESE MARTIN · 2005 to 2026
$13.5M
NIMH NIH HHS R01 MH074090
6 · The paper itself

Abstract

Genomic imbalances involving the telomeric regions of human chromosomes, which contain the highest gene concentration in the genome, are proposed to have severe phenotypic consequences. For this reason, it is important to identify telomere rearrangements and assess their contribution to human pathology. This unit describes the structure and function of human telomeres and outlines several methodologies that can be employed to study these unique regions of human chromosomes. It is a revision of the original version of the unit published in 2000, now including an introductory section describing advances in the discipline that have taken place since the original publication.

Indexed as

Gene RearrangementChromosomes, HumanComparative Genomic HybridizationDNA ProbesFluorescent DyesGene DosageGenomic InstabilityHumansIn Situ Hybridization, FluorescenceTelomereTranslocation, GeneticDNA ProbesFluorescent Dyeschromosomal microarraycopy number variantstelomere

Identifiers

PMID25599669
PMCPMC4410364

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.