ArticleThe Laryngoscope2015
Noninvasive depth-resolved optical measurements of the tympanic membrane and middle ear for differentiating otitis media.
Article in The Laryngoscope, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
50 citing papers in PubMed, 87 citations in OpenAlex.
- Optical assessment of the in vivo tympanic membrane status using a handheld optical coherence tomography-based otoscope.Acta oto-laryngologica · 2018Trial
- Quantitative Pneumatic Otoscopy Using a Light-Based Ranging Technique.Journal of the Association for Research in Otolaryngology : JARO · 2017Trial
- Differentiating Causes of Post-Surgical Conductive Hearing Loss with Optical Coherence Tomography Vibrometry.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Artificial Intelligence in Label-Free Optical Imaging Applications.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Quantitative measurement of tympanic membrane structure and symmetry with optical coherence tomography in normal human subjects.Journal of biomedical optics · 2025Article
- Visualizing motions within the cochlea's organ of Corti and illuminating cochlear mechanics with optical coherence tomography.Hearing research · 2025Review
- Texture-based speciation of otitis media-related bacterial biofilms from optical coherence tomography images using supervised classification.Journal of biophotonics · 2024Article
- Label-Free Optical Technologies for Middle-Ear Diseases.Bioengineering (Basel, Switzerland) · 2024Review
- Non-rigid point cloud registration for middle ear diagnostics with endoscopic optical coherence tomography.International journal of computer assisted radiology and surgery · 2024Article
- In Vivo Optical Characterization of Middle Ear Effusions and Biofilms During Otitis Media.Journal of the Association for Research in Otolaryngology : JARO · 2023Observational
- Finite-Element Modelling Based on Optical Coherence Tomography and Corresponding X-ray MicroCT Data for Three Human Middle Ears.Journal of the Association for Research in Otolaryngology : JARO · 2023Article
- Otoendoscopy in the era of narrow-band imaging: a pictorial review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Article
- Automated classification of otitis media with OCT: augmenting pediatric image datasets with gold-standard animal model data.Biomedical optics express · 2022Article
- Ex vivo transtympanic permeation of the liposome encapsulated S. pneumoniae endolysin MSlys.International journal of pharmaceutics · 2022Article
- Differentiation of otitis media-causing bacteria and biofilmsFrontiers in cellular and infection microbiology · 2022Article
- New Approaches and Technologies to Improve Accuracy of Acute Otitis Media Diagnosis.Diagnostics (Basel, Switzerland) · 2021Review
- Enhanced medical diagnosis for dOCTors: a perspective of optical coherence tomography.Journal of biomedical optics · 2021Review
- In vivo functional imaging of the human middle ear with a hand-held optical coherence tomography device.Biomedical optics express · 2021Article
- A review of low-cost and portable optical coherence tomography.Progress in biomedical engineering (Bristol, England) · 2021Article
- Inactivation and sensitization of Pseudomonas aeruginosa by microplasma jet array for treating otitis media.NPJ biofilms and microbiomes · 2021Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
objective/hypothesisIn this study, optical coherence tomography (OCT) is used to noninvasively and quantitatively determine tympanic membrane (TM) thickness and the presence and thickness of any middle-ear biofilm located behind the TM. These new metrics offer the potential to differentiate normal, acute, and chronic otitis media (OM) infections in pediatric subjects. STUDY
designCase series with comparison group.
methodsThe TM thickness of 34 pediatric subjects was acquired using a custom-built, handheld OCT system following a traditional otoscopic ear exam.
resultsOverall thickness (TM and any associated biofilm) was shown to be statistically different for normal, acute, and chronic infection groups (normal-acute and normal-chronic: P value < 0.001; acute-chronic: P value = 0.0016). Almost all observed scans from the chronic group had an accompanying biofilm structure. When the thickness of the TM and biofilm were considered separately in chronic OM, the chronic TM thickness correlated with the normal group (P value = 0.68) yet was still distinct from the acute OM group (P value < 0.001), indicating that the TM in chronic OM returns to relatively normal thickness levels.
conclusionIdentifying these physical changes in vivo provides new metrics for noninvasively and quantitatively differentiating normal, acute, and chronic OM. This new diagnostic information has the potential to assist physicians to more effectively and efficiently screen, manage, and refer patients based on quantitative data. LEVEL OF EVIDENCE: 4.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.