ArticleNutrition & diabetes2015
Altered functional connectivity within the central reward network in overweight and obese women.
Article in Nutrition & diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Neuroimaging Investigations of Obesity: a Review of the Treatment of Sex from 2010.Current obesity reports · 2023Pooled it
- Body size estimation in obesity: a systematic review and meta-analysis.Experimental brain research · 2021Pooled it
- The CB1 Neutral Antagonist Tetrahydrocannabivarin Reduces Default Mode Network and Increases Executive Control Network Resting State Functional Connectivity in Healthy Volunteers.The international journal of neuropsychopharmacology · 2015Trial
- Large-Scale Brain Network Connectivity Mediates the Association Between Metabolic Risk Factors and Cognition: An fMRI Study of the Human Connectome Project.International journal of endocrinology and metabolism · 2026Article
- Machine learning-based identification of abnormal functional connectivity in obesity across different metabolic states.Communications medicine · 2026Article
- Resting-state brain dynamics are associated with body fat percentage and sympathetic outflow in healthy adults.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Regional brain glucose uptake following gastric bypass surgery during normo- and hypoglycemic clamp: a pilot FDG-PET study.Endocrine · 2025Article
- Neural Markers of Treatment Response in Pediatric Anxiety and PTSD.Current topics in behavioral neurosciences · 2025Review
- Early life adversity impacts alterations in brain structure and food addiction in individuals with high BMI.Scientific reports · 2024Article
- Excess BMI in early adolescence adversely impacts maturating functional circuits supporting high-level cognition and their structural correlates.International journal of obesity (2005) · 2023Article
- Article
- Aberrant impulse control circuitry in obesity.Molecular psychiatry · 2022Article
- Alterations in Functional and Structural Connectivity of Basal Ganglia Network in Patients with Obesity.Brain topography · 2022Article
- Article
- Effects of bariatric surgery on functional connectivity of the reward and default mode network: A pre-registered analysis.Human brain mapping · 2021Article
- Obese Individuals Show Disrupted Dynamic Functional Connectivity between Basal Ganglia and Salience Networks.Cerebral cortex (New York, N.Y. : 1991) · 2021Article
- Inter-individual body mass variations relate to fractionated functional brain hierarchies.Communications biology · 2021Article
- Resting-state connectivity within the brain's reward system predicts weight loss and correlates with leptin.Brain communications · 2021Article
- A review of the relationship between eating behavior, obesity and functional brain network organization.Social cognitive and affective neuroscience · 2020Review
- Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
BACKGROUND/
objectivesNeuroimaging studies in obese subjects have identified abnormal activation of key regions of central reward circuits, including the nucleus accumbens (NAcc), in response to food-related stimuli. We aimed to examine whether women with elevated body mass index (BMI) show structural and resting state (RS) functional connectivity alterations within regions of the reward network. SUBJECTS/
methodsFifty healthy, premenopausal women, 19 overweight and obese (high BMI=26-38 kg m(-2)) and 31 lean (BMI=19-25 kg m(-2)) were selected from the University of California Los Angeles' Oppenheimer Center for Neurobiology of Stress database. Structural and RS functional scans were collected. Group differences in grey matter volume (GMV) of the NAcc, oscillation dynamics of intrinsic brain activity and functional connectivity of the NAcc to regions within the reward network were examined.
resultsGMV of the left NAcc was significantly greater in the high BMI group than in the lean group (P=0.031). Altered frequency distributions were observed in women with high BMI compared with lean group in the left NAcc (P=0.009) in a medium-frequency (MF) band, and in bilateral anterior cingulate cortex (ACC) (P=0.014, <0.001) and ventro-medial prefrontal cortex (vmPFC) (P=0.034, <0.001) in a high-frequency band. Subjects with high BMI had greater connectivity of the left NAcc with bilateral ACC (P=0.024) and right vmPFC (P=0.032) in a MF band and with the left ACC (P=0.03) in a high frequency band.
conclusionsOverweight and obese women in the absence of food-related stimuli show significant structural and functional alterations within regions of reward-related brain networks, which may have a role in altered ingestive behaviors.
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Registered trials
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