Evidence map›Paper›PMID 25599463›Full record

ArticleCritical care medicine2015

Fluid management with a simplified conservative protocol for the acute respiratory distress syndrome*.

Colin K Grissom, Eliotte L Hirshberg, Justin B Dickerson, Samuel M Brown, Michael J Lanspa, Kathleen D Liu, David Schoenfeld, Mark Tidswell, R Duncan Hite, Peter Rock and 3 more

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02759770 (Risk Factors and Prediction Score of ARDS After Cardiac Surgery), which is not on this map. Cited by 58 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 2 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02759770 completednot on this mapstarted 2017, after this paper: background citation

Risk Factors and Prediction Score of ARDS After Cardiac Surgery

TypeobservationalSponsorBeijing Anzhen HospitalRan2017 to 2017Enrolled1,333ConditionsRespiratory Distress Syndrome, Adult, Thoracic Surgery, Risk FactorsArmsno intervention
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 2 syntheses or guidelines pooled it, 129 citations in OpenAlex.

  1. Guideline
  2. Pooled it
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  9. Article
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  11. Evaluation of the Effects of a Combination of Vitamin C, Thiamine and Hydrocortisone vs Hydrocortisone Alone on ICU Outcome in Patients with Septic Shock: A Randomized Controlled Trial.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2024
    Article
  12. Article
  13. A New Era in Critical Care Trials: Linking ICU Practice to Long-Term Outcomes.American journal of respiratory and critical care medicine · 2024
    Article
  14. Review
  15. Fluids in the ICU: which is the right one?Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2023
    Review
  16. Article
  17. Review
  18. Article
  19. Care of the Seriously Ill Patient with SARS-CoV-2.The Medical clinics of North America · 2022
    Review
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 7 institutions in 1 country.

Colin K Grissom1Division of Critical Care Medicine, Intermountain Medical Center, Murray, UT. 2Division of Pulmonary and Critical Care, Department of Medicine, University of Utah, Salt Lake City, UT. 3Division of Pediatric Critical Care, University of Utah, Salt Lake City, UT. 4College of Pharmacy, University of Utah, Salt Lake City, UT. 5Division of Nephrology, University of California San Francisco, San Francisco, CA. 6Division of Critical Care Medicine, University of California San Francisco, San Francisco, CA. 7Biostatistics Center, Massachusetts General Hospital, Boston, MA. 8Division of Pulmonary and Critical Care Medicine, Baystate Medical Center, Springfield, MA. 9Respiratory Institute, Cleveland Clinic, Cleveland, OH. 10Department of Anesthesiology, University of Maryland, Baltimore, MD.
Eliotte L Hirshberg
Justin B Dickerson
Samuel M Brown
Michael J Lanspa
Kathleen D Liu
David Schoenfeld
Mark Tidswell
R Duncan Hite
Peter Rock
Russell R Miller
Alan H Morris
National Heart Lung and Blood Institute Acute Respiratory Distress Syndrome Clinical Trials Network
Primary Children's Hospital · USUniversity of Utah · USBaystate Medical Center · USCleveland Clinic · USHarvard University Press · USUniversity of California, San Francisco · USUniversity of Maryland, Baltimore · US

Funding

Long Term Outcomes and Macrophage Biology in Patients with EVALIU01HL123018 · NHLBI · IHC HEALTH SERVICES, INC. · PI BLEDSOE, JOSEPH R, BROWN, SAMUEL MORRIS · 2014 to 2020
$2.4M
CLINICAL CENTERS--A NETWORK FOR THE TREAMENT OF ARDN01HR046062 · HR · LDS HOSPITAL · PI MORRIS, ALAN H · 1994 to 2000
$645k
Cardiovascular Variability and Control in Early SepsisK23GM094465 · NIGMS · IHC HEALTH SERVICES, INC. · PI BROWN, SAMUEL MORRIS · 2010 to 2014
$637k
NHLBI NIH HHS N01 HR046062NHLBI NIH HHS U01 HL123018NIGMS NIH HHS K23 GM094465NIGMS NIH HHS K23GM094465PHS HHS HHSN268200536165CPHS HHS HHSN268200536171CPHS HHS HHSN268200536179C
6 · The paper itself

Abstract

objectivesIn the Fluid and Catheter Treatment Trial (FACTT) of the National Institutes of Health Acute Respiratory Distress Syndrome Network, a conservative fluid protocol (FACTT Conservative) resulted in a lower cumulative fluid balance and better outcomes than a liberal fluid protocol (FACTT Liberal). Subsequent Acute Respiratory Distress Syndrome Network studies used a simplified conservative fluid protocol (FACTT Lite). The objective of this study was to compare the performance of FACTT Lite, FACTT Conservative, and FACTT Liberal protocols.

designRetrospective comparison of FACTT Lite, FACTT Conservative, and FACTT Liberal. Primary outcome was cumulative fluid balance over 7 days. Secondary outcomes were 60-day adjusted mortality and ventilator-free days through day 28. Safety outcomes were prevalence of acute kidney injury and new shock.

settingICUs of Acute Respiratory Distress Syndrome Network participating hospitals. PATIENTS: Five hundred three subjects managed with FACTT Conservative, 497 subjects managed with FACTT Liberal, and 1,124 subjects managed with FACTT Lite.

interventionsFluid management by protocol. MEASUREMENTS AND MAIN

resultsCumulative fluid balance was 1,918 ± 323 mL in FACTT Lite, -136 ± 491 mL in FACTT Conservative, and 6,992 ± 502 mL in FACTT Liberal (p < 0.001). Mortality was not different between groups (24% in FACTT Lite, 25% in FACTT Conservative and Liberal, p = 0.84). Ventilator-free days in FACTT Lite (14.9 ± 0.3) were equivalent to FACTT Conservative (14.6 ± 0.5) (p = 0.61) and greater than in FACTT Liberal (12.1 ± 0.5, p < 0.001 vs Lite). Acute kidney injury prevalence was 58% in FACTT Lite and 57% in FACTT Conservative (p = 0.72). Prevalence of new shock in FACTT Lite (9%) was lower than in FACTT Conservative (13%) (p = 0.007 vs Lite) and similar to FACTT Liberal (11%) (p = 0.18 vs Lite).

conclusionsFACTT Lite had a greater cumulative fluid balance than FACTT Conservative but had equivalent clinical and safety outcomes. FACTT Lite is an alternative to FACTT Conservative for fluid management in Acute Respiratory Distress Syndrome.

Indexed as

Intensive Care UnitsCentral Venous PressureClinical ProtocolsDiureticsFemaleFluid TherapyFurosemideHumansMaleMiddle AgedRandom AllocationRespiration, ArtificialRespiratory Distress SyndromeRetrospective StudiesShockUnited StatesDiureticsFurosemide

Identifiers

PMID25599463
PMCPMC4675623
OpenAlexW1990771406

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.