ArticleThe Journal of investigative dermatology2015
MMP-1 and -3 promoter variants are indicative of a common susceptibility for skin and lung aging: results from a cohort of elderly women (SALIA).
Article in The Journal of investigative dermatology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 36 citations in OpenAlex.
- Global periorbital skin rejuvenation by a topical eye cream containing low molecular weight heparan sulfate (LMW-HS) and a blend of naturally derived extracts.Journal of cosmetic dermatology · 2019Trial
- Integrative Machine Learning of Genetic and Lifestyle Factors for Personalized Skin Health.IEEE journal of translational engineering in health and medicine · 2026Article
- Chondrodermatitis Nodularis Helicis: Association with Higher Risk of Multimorbidity and Mortality in Middle-Aged Individuals and Implications for Prevention. An Observational Multicenter Retrospective Case-Control Investigation in Northern Spain.Dermatology practical & conceptual · 2025Article
- Genetic profiling and precision skin care: a review.Frontiers in genetics · 2025Review
- Excessive Facial Wrinkling Is Associated with COPD Occurrence-Does COPD Damage Skin Beauty and Quality?International journal of environmental research and public health · 2023Article
- Prediction and association analyses of skin phenotypes in Japanese females using genetic, environmental, and physical features.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023Article
- Oxidative contribution of air pollution to extrinsic skin ageing.Free radical biology & medicine · 2020Review
- Air Pollution and Skin Aging.Current environmental health reports · 2020Review
- Loss of skin elasticity is associated with pulmonary emphysema, biomarkers of inflammation, and matrix metalloproteinase activity in smokers.Respiratory research · 2019Article
- Environmental Stressors on Skin Aging. Mechanistic Insights.Frontiers in pharmacology · 2019Review
- Prevalence of skin diseases in hospitalized geriatric patients : Association with gender, duration of hospitalization and geriatric assessment.Zeitschrift fur Gerontologie und Geriatrie · 2017Article
- Pathways of aging: comparative analysis of gene signatures in replicative senescence and stress induced premature senescence.BMC genomics · 2016Article
- [Skin aging: Molecular understanding of extrinsic and intrinsic processes].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Studies have indicated that there may be a smoking-dependent association between skin wrinkling and airflow obstruction of the lung. It was suggested that this association might be because of an underlying susceptibility in genes responsible for extracellular matrix (ECM) remodeling. Our purpose was to confirm the association between skin wrinkling and airflow obstruction and to identify genetic polymorphisms indicative of an underlying susceptibility. In 697 elderly women, we assessed skin wrinkles by SCINEXA (SCore for INtrinsic and EXtrinsic skin Aging) and airflow obstruction by spirometry, using the ratio of forced expiratory volume in 1 second (FEV1) to forced volume capacity (FVC). For association analysis, we used multiple regression and found that the FEV1/FVC ratio decreased 1.2% per 6-point increase in the wrinkle severity score after accounting for age, education, body mass index, skin type, and sun exposure. This association was significant and independent of smoking or air pollution. Most interestingly, this association occurred only in carriers of the matrix metalloproteinase-1 (MMP-1) 2G (rs1799750) or the MMP-3 6A (rs3025058) allele but not in homozygous carriers of the 1G or 5A allele. Thus, skin and lung aging are linked in carriers of the 2G or 6A allele. These alleles appear to be indicative of a common genetic susceptibility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.