Evidence map›Paper›PMID 25599385›Full record

Trial reportThe Journal of clinical endocrinology and metabolism2015

Combined training enhances skeletal muscle mitochondrial oxidative capacity independent of age.

Brian A Irving, Ian R Lanza, Gregory C Henderson, Rajesh R Rao, Bruce M Spiegelman, K Sreekumaran Nair

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 76 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
76citing papers in PubMed, 10 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

76 citing papers in PubMed, 10 syntheses or guidelines pooled it.

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  4. Standard Deviation of Individual Response for VOSports medicine (Auckland, N.Z.) · 2024
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  15. Mitochondrial respiration variability and simulations in human skeletal muscle: The Gene SMART study.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
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16 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors.

Brian A IrvingDivision of Endocrinology (B.A.I., I.R.L., G.D.H., K.S.N.), Endocrine Research Unit, Mayo Clinic College of Medicine, Rochester, Minnesota 55905; Department of Cancer Biology (R.R.R., B.M.S.), Dana-Farber Cancer Institute, Boston, Massachusetts 02215; and Department of Cell Biology (R.R.R., B.M.S.), Harvard Medical School, Boston, Massachusetts 02215.
Ian R Lanza
Gregory C Henderson
Rajesh R Rao
Bruce M Spiegelman
K Sreekumaran Nair

Funding

Mayo Clinic Center for Translational Science ActivitiesUL1TR000135 · NCATS · MAYO CLINIC ROCHESTER · PI KHOSLA, SUNDEEP · 2012 to 2015
$41.2M
Mayo Clinic Center for Translational Science ActivitiesKL2RR024151 · NCRR · MAYO CLINIC ROCHESTER · PI RIZZA, ROBERT A. · 2006 to 2011
$15.3M
MECHANISM OF MUSCLE WASTING IN AGING MANR01AG009531 · NIA · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI NAIR, K SREEKUMARAN · 1993 to 2014
$8.8M
IN VIVO REGULATION OF PROTEIN TURNOVER BY HORMONESR01DK041973 · NIDDK · UNIVERSITY OF VERMONT &ST AGRIC COLLEGE · PI NAIR, K SREEKUMARAN · 1989 to 2014
$7.3M
NCATS NIH HHS UL1 TR000135NCATS NIH HHS UL1-TR000135NCRR NIH HHS KL2 RR024151NCRR NIH HHS KL2RR024151NIA NIH HHS R01 AG009531NIA NIH HHS R01AG09531NIDDK NIH HHS R01 DK041973NIDDK NIH HHS R01DK41973
6 · The paper itself

Abstract

contextSkeletal muscle from sedentary older adults exhibits reduced mitochondrial abundance and oxidative capacity.

objectiveThe primary objective was to determine whether 8 weeks of combined training (CT) has a more robust effect than endurance training (ET) or resistance training (RT) on mitochondrial physiology in healthy young (18-30 years) and older (≥ 65 years) adults.

interventionThirty-four young and 31 older adults were randomly assigned to 8 weeks of ET, RT, and control/CT. Control subjects completed 8 weeks of no exercise (control) followed by 8 weeks of CT. Body composition, skeletal muscle strength, and peak oxygen uptake were measured before and after the intervention. Vastus lateralis muscle biopsy samples were obtained before and 48 hours after the intervention. Mitochondrial physiology was evaluated by high-resolution respirometry and expression of mitochondrial proteins and transcription factors by quantitative PCR and immunoblotting.

resultsET and CT significantly increased oxidative capacity and expression of mitochondrial proteins and transcription factors. All training modalities improved body composition, cardiorespiratory fitness, and skeletal muscle strength. CT induced the most robust improvements in mitochondria-related outcomes and physical characteristics despite lower training volumes for the ET and RT components. Importantly, most of the adaptations to training occurred independent of age.

conclusionCollectively, these results demonstrate that both ET and CT increase muscle mitochondrial abundance and capacity although CT induced the most robust improvements in the outcomes measured. In conclusion, CT provides a robust exercise regimen to improve muscle mitochondrial outcomes and physical characteristics independent of age.

Indexed as

Oxygen ConsumptionAdolescentAdultAgedAge FactorsAgingExerciseFemaleHumansMaleMitochondria, MuscleMuscle, SkeletalOxidation-ReductionPhysical EnduranceResistance TrainingYoung Adult

Identifiers

PMID25599385
PMCPMC4399307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.