ReviewAnnals of surgery2015
The status of contemporary image-guided modalities in oncologic surgery.
Review in Annals of surgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04734821 (Prospective Study on the Contribution of Fluorescence in the Guidance of Lymphadenectomy and in Peroperative Evaluation of Pre-anastomotic Tissue Perfusion in Laparoscopic Esogastric Oncologic Resections), which is not on this map. Cited by 72 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Study on the Contribution of Fluorescence in the Guidance of Lymphadenectomy and in Peroperative Evaluation of Pre-anastomotic Tissue Perfusion in Laparoscopic Esogastric Oncologic Resections
Who cites it
72 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Novel imaging techniques for intraoperative margin assessment in surgical oncology: A systematic review.International journal of cancer · 2021Pooled it
- Oncologic Procedures Amenable to Fluorescence-guided Surgery.Annals of surgery · 2017Pooled it
- Use of Ultrasmall Core-Shell Fluorescent Silica Nanoparticles for Image-Guided Sentinel Lymph Node Biopsy in Head and Neck Melanoma: A Nonrandomized Clinical Trial.JAMA network open · 2021Trial
- Characterizing the Utility and Limitations of Repurposing an Open-Field Optical Imaging Device for Fluorescence-Guided Surgery in Head and Neck Cancer Patients.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2017Trial
- Fluorescence-Guided Surgery of Rhabdomyosarcoma Using a B7-H3 Targeted Antibody-Fluorophore Conjugate.Molecular pharmaceutics · 2026Article
- Nanotechnology-enabled precision strategies for bladder cancer: from in vitro diagnostics to in vivo therapy.Journal of nanobiotechnology · 2026Review
- From Image-Guided Surgery to Computer-Assisted Real-Time Diagnosis with Hyperspectral and Multispectral Imaging: A Systematic Review in Gynecologic Oncology.Diagnostics (Basel, Switzerland) · 2026Review
- Rapid Arbitrary-Shape Microscopy of Unsectioned Tissues for Precise Intraoperative Tumor Margin Assessment.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Synthesis and preclinical evaluation of FAP-targeting radiotracers for PET and optical imaging.EJNMMI radiopharmacy and chemistry · 2025Article
- Deep learning-enabled fluorescence imaging for oral cancer margin classification in preclinical models.Journal of biomedical optics · 2025Article
- Advanced Image-Guidance and Surgical-Navigation Techniques for Real-Time Visualized Surgery.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Personalized Medical Approach in Gastrointestinal Surgical Oncology: Current Trends and Future Perspectives.Journal of personalized medicine · 2025Review
- Fluorescence-guided Surgery for Hepatocellular Carcinoma: From Clinical Practice to Laboratories.Journal of clinical and translational hepatology · 2025Review
- Tracking the Fate of Therapeutic Proteins Using Ratiometric Imaging of Responsive Shortwave Infrared Probes.Journal of the American Chemical Society · 2025Article
- Deep learning-enabled fluorescence imaging for surgical guidance:Journal of biomedical optics · 2025Article
- Characterizing the accuracy of robotic bronchoscopy in localization & targeting of small pulmonary lesions.International journal of computer assisted radiology and surgery · 2024Article
- Current clinical applications of Cerenkov luminescence for intraoperative molecular imaging.European journal of nuclear medicine and molecular imaging · 2024Review
- Assessing the accuracy of a multisection robotic bronchoscope prototype in localization and targeting of small pulmonary lesions.JTCVS techniques · 2024Article
- Evaluating the Margins of Breast Cancer Tumors by Using Digital Breast Tomosynthesis with Deep Learning: A Preliminary Assessment.Diagnostics (Basel, Switzerland) · 2024Article
- Validation of a semi-quantitative scoring system and workflow for analysis of fluorescence quantification in companion animals.Frontiers in veterinary science · 2024Article
12 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
objectiveTo review the current trends in optical imaging to guide oncologic surgery.
backgroundSurgical resection remains the cornerstone of therapy for patients with early stage solid malignancies and more than half of all patients with cancer undergo surgery each year. The technical ability of the surgeon to obtain clear surgical margins at the initial resection remains crucial to improve overall survival and long-term morbidity. Current resection techniques are largely based on subjective and subtle changes associated with tissue distortion by invasive cancer. As a result, positive surgical margins occur in a significant portion of tumor resections, which is directly correlated with a poor outcome.
methodsA comprehensive review of studies evaluating optical imaging techniques is performed.
resultsA variety of cancer imaging techniques have been adapted or developed for intraoperative surgical guidance that have been shown to improve functional and oncologic outcomes in randomized clinical trials. There are also a large number of novel, cancer-specific contrast agents that are in early stage clinical trials and preclinical development that demonstrate significant promise to improve real-time detection of subclinical cancer in the operative setting.
conclusionsThere has been an explosion of intraoperative imaging techniques that will become more widespread in the next decade.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.