Trial reportPain2015
Preoperative widespread pain sensitization and chronic pain after hip and knee replacement: a cohort analysis.
Trial report in Pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03389906 (Inflammation Impact on Pain in Patients With Knee Osteoarthritis), which is not on this map. Cited by 50 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Inflammation Impact on Pain in Patients With Knee Osteoarthritis
Who cites it
50 citing papers in PubMed, 2 syntheses or guidelines pooled it, 138 citations in OpenAlex.
- Different genes may be involved in distal and local sensitization: A genome-wide gene-based association study and meta-analysis.European journal of pain (London, England) · 2022Pooled it
- Pooled it
- Effect of different low doses of intrathecal morphine (0.1 and 0.2 mg) on pain and vital functions in patients undergoing total hip arthroplasty: a randomised controlled study.BMC anesthesiology · 2022Trial
- Trial
- Short- and long-term impact of remifentanil on thermal detection and pain thresholds after cardiac surgery: A randomised controlled trial.European journal of anaesthesiology · 2019Trial
- Course of pain after total hip arthroplasty within a standardized pain management concept: a prospective study examining influence, correlation, and outcome of postoperative pain on 103 consecutive patients.Archives of orthopaedic and trauma surgery · 2018Trial
- Trial
- Chronic Pain and Stiffness After Total Knee Arthroplasty: A Comprehensive, Phenotype-Based Review of Mechanisms, Diagnosis and Management.Journal of clinical medicine · 2026Review
- Biopsychosocial predictive factors for developing chronic postsurgical pain after hip replacement surgery: A systematic review.Osteoarthritis and cartilage open · 2026Review
- Six-Week Changes in Pain Biomarkers Following Reverse Total Shoulder Arthroplasty: A Prospective Cohort Study.medRxiv : the preprint server for health sciences · 2026Article
- Does the preoperative presence of central sensitization affect sleep quality and pain after total knee arthroplasty?Turkish journal of physical medicine and rehabilitation · 2025Article
- "Pain Prehabilitation" in Major Joint Surgery: The Way Forward to Improve Outcomes and Prevent Pain Chronicity.Journal of clinical medicine · 2025Review
- Impact of preoperative factors on clinical outcomes after total hip arthroplasty.World journal of orthopedics · 2025Article
- Mediating role of pain sensitization in preoperative and postoperative pain in knee osteoarthritis patients.European journal of medical research · 2025Article
- Pressure dispersion pad use allows patients to kneel comfortably after total knee arthroplasty.Journal of experimental orthopaedics · 2025Article
- The importance of central sensitization for clinical trials of disease modifying osteoarthritis drugs (DMOADs).Osteoarthritis imaging · 2025Article
- Lateral Femoral Cutaneous Nerve Block or Wound Infiltration Combined with Pericapsular Nerve Group (PENG) Block for Postoperative Analgesia following Total Hip Arthroplasty through Posterior Approach: A Randomized Controlled Trial.Journal of clinical medicine · 2024Article
- Mechanisms and Preventative Strategies for Persistent Pain following Knee and Hip Joint Replacement Surgery: A Narrative Review.International journal of molecular sciences · 2024Review
- The relationship between inadequate response to physical therapy and central sensitization in patients with knee osteoarthritis: A prospective cohort study.Turkish journal of physical medicine and rehabilitation · 2023Article
- Relation of pain sensitization to self-reported and performance-based measures of physical functioning: the Multicenter Osteoarthritis (MOST) study.Osteoarthritis and cartilage · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic pain after joint replacement is common, affecting approximately 10% of patients after total hip replacement (THR) and 20% of patients after total knee replacement (TKR). Heightened generalized sensitivity to nociceptive input could be a risk factor for the development of this pain. The primary aim of this study was to investigate whether preoperative widespread pain sensitivity was associated with chronic pain after joint replacement. Data were analyzed from 254 patients receiving THR and 239 patients receiving TKR. Pain was assessed preoperatively and at 12 months after surgery using the Western Ontario and McMaster Universities Osteoarthritis Pain Scale. Preoperative widespread pain sensitivity was assessed through measurement of pressure pain thresholds (PPTs) at the forearm using an algometer. Statistical analysis was conducted using linear regression and linear mixed models, and adjustments were made for confounding variables. In both the THR and TKR cohort, lower PPTs (heightened widespread pain sensitivity) were significantly associated with higher preoperative pain severity. Lower PPTs were also significantly associated with higher pain severity at 12 months after surgery in the THR cohort. However, PPTs were not associated with the change in pain severity from preoperative to 12 months postoperative in either the TKR or THR cohort. These findings suggest that although preoperative widespread pressure pain sensitivity is associated with pain severity before and after joint replacement, it is not a predictor of the amount of pain relief that patients gain from joint replacement surgery, independent of preoperative pain severity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.