ArticlePain2015
Heritability of pain catastrophizing and associations with experimental pain outcomes: a twin study.
Article in Pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed.
- The Impact of Catastrophization and Emotions on Pain: A Narrative Review of Underlying Mechanisms.Journal of pain research · 2026Review
- Parental opioid prescriptions and the risk of opioid use in adolescents and young adults: The HUNT Study linked with prescription registry data.PLoS medicine · 2025Article
- Effects of biopsychosocial complexity and pain-related factors on opioid prescription in patients with chronic musculoskeletal pain.Pain reports · 2025Article
- Experimental Pain Sensitivity and Parental Pain Catastrophizing.Children (Basel, Switzerland) · 2024Article
- The Negative Effect of Social Discrimination on Pain Tolerance and the Moderating Role of Pain Catastrophizing.Journal of clinical psychology in medical settings · 2023Article
- Catastrophizing and acceptance are mediators between insomnia and pain intensity-an SQRP study of more than 6,400 patients with non-malignant chronic pain conditions.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Specific and common mediators of gastrointestinal symptom improvement in patients undergoing education/support vs. cognitive behavioral therapy for irritable bowel syndrome.Journal of consulting and clinical psychology · 2021Article
- Behavioral-genetic associations in the Human Connectome Project.Experimental brain research · 2020Article
- Psychological and Genetic Predictors of Pain Tolerance.Clinical and translational science · 2019Article
- Are Individual Learning Experiences More Important Than Heritable Tendencies? A Pilot Twin Study on Placebo Analgesia.Frontiers in psychiatry · 2019Article
- Evaluating psychosocial contributions to chronic pain outcomes.Progress in neuro-psychopharmacology & biological psychiatry · 2018Review
- Article
- Placebo and Nocebo Effects: The Advantage of Measuring Expectations and Psychological Factors.Frontiers in psychology · 2017Article
- Transmission of risk from parents with chronic pain to offspring: an integrative conceptual model.Pain · 2016Review
- The Role of Psychosocial Processes in the Development and Maintenance of Chronic Pain.The journal of pain · 2016Review
- Article
- Pain Catastrophizing Predicts Menstrual Pain Ratings in Adolescent Girls with Chronic Pain.Pain medicine (Malden, Mass.) · 2016Article
- Article
- Childhood adversities and laboratory pain perception.Neuropsychiatric disease and treatment · 2015Article
- Genetic associations of perinatal pain and depression.Molecular painArticle
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Authors and funding
6 authors.
Funding
Abstract
This study used a twin paradigm to examine genetic and environmental contributions to pain catastrophizing and the observed association between pain catastrophizing and cold-pressor task (CPT) outcomes. Male and female monozygotic (n = 206) and dizygotic twins (n = 194) from the University of Washington Twin Registry completed a measure of pain catastrophizing and performed a CPT challenge. As expected, pain catastrophizing emerged as a significant predictor of several CPT outcomes, including cold-pressor Immersion Tolerance, Pain Tolerance, and Delayed Pain Rating. The heritability estimate for pain catastrophizing was found to be 37% with the remaining 63% of variance attributable to unique environmental influence. Additionally, the observed associations between pain catastrophizing and CPT outcomes were not found attributable to shared genetics or environmental exposure, which suggests a direct relationship between catastrophizing and experimental pain outcomes. This study is the first to examine the heritability of pain catastrophizing and potential processes by which pain catastrophizing is related to experimental pain response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.