Evidence map›Paper›PMID 25599204›Full record

ArticleNeurosurgery2015

Adverse events associated with deep brain stimulation for movement disorders: analysis of 510 consecutive cases.

Daxa M Patel, Harrison C Walker, Rebekah Brooks, Nidal Omar, Benjamin Ditty, Barton L Guthrie

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurosurgery, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02288468 (One Pass thalamIc aNd subthalamIc stimulatiON), which is not on this map. Cited by 46 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
46citing papers in PubMed, 6 pooled it
9.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02288468 nacompletednot on this map

One Pass thalamIc aNd subthalamIc stimulatiON

TypeinterventionalSponsorUniversity Hospital FreiburgRan2015 to 2020Enrolled12ConditionsParkinson's DiseaseArmsVercise™ Deep Brain Stimulation System
3 · Its place in the literature

Who cites it

46 citing papers in PubMed, 6 syntheses or guidelines pooled it, 93 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Daxa M Patel‡Division of Neurosurgery, The University of Alabama at Birmingham, Birmingham, Alabama; §Division of Neurology, The University of Alabama at Birmingham, Birmingham, Alabama; ¶Department of Biomedical Engineering, The University of Alabama at Birmingham, Birmingham, Alabama; ‖School of Medicine, The University of Alabama at Birmingham, Birmingham, Alabama.
Harrison C Walker
Rebekah Brooks
Nidal Omar
Benjamin Ditty
Barton L Guthrie
University of Alabama at Birmingham · US

Funding

Clinical and neurophysiological study of subthalamic brain stimulation in PDK23NS067053 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WALKER, HARRISON CARROLL · 2010 to 2014
$877k
NINDS NIH HHS K23 NS067053
6 · The paper itself

Abstract

backgroundAlthough numerous studies have focused on the efficacy of deep brain stimulation (DBS) for movement disorders, less is known about surgical adverse events, especially over longer time intervals.

objectiveHere, we analyze adverse events in 510 consecutive cases from a tertiary movement disorders center at up to 10 years postoperatively.

methodsWe conducted a retrospective review of adverse events from craniotomies between January 2003 and March 2013. The adverse events were categorized into 2 broad categories--immediate perioperative and time-dependent postoperative events.

resultsAcross all targets, perioperative mental status change occurred in 18 (3.5%) cases, and symptomatic intracranial hemorrhage occurred in 4 (0.78%) cases. The most common hardware-related event was skin erosion in 13 (2.5%) cases. The most frequent stimulation-related event was speech disturbance in 16 (3.1%) cases. There were no significant differences among surgical targets with respect to the incidence of these events. Time-dependent postoperative events leading to the revision of a given DBS electrode for any reason occurred in 4.7% ± 1.0%, 9.3% ± 1.4%, and 12.4% ± 1.5% of electrodes at 1, 4, and 7 years postoperatively, respectively. Staged bilateral DBS was associated with approximately twice the risk of repeat surgery for electrode replacement vs unilateral surgery (P = .020).

conclusionThese data provide low incidences for adverse events in a large series of DBS surgeries for movement disorders at up to 10 years follow-up. Accurate estimates of adverse events will better inform patients and caregivers about the potential risks and benefits of surgery and provide normative data for process improvement.

Indexed as

AdolescentAdultAgedCraniotomyDeep Brain StimulationElectrodes, ImplantedFemaleHumansIncidenceMaleMiddle AgedMovement DisordersPostoperative ComplicationsRetrospective Studies

Identifiers

PMID25599204
PMCPMC12129402
OpenAlexW2318752784

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.