ArticleJournal of medicinal food2015
Antioxidant Effect of Spirulina (Arthrospira) maxima on Chronic Inflammation Induced by Freund's Complete Adjuvant in Rats.
Article in Journal of medicinal food, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Spirulina supplementation and rheumatoid arthritis: A systematic review of current research and molecular mechanisms.Molecular biology reports · 2025Pooled it
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- Microalgae's polysaccharides, are they potent antioxidants? Critical review.Archives of microbiology · 2023Review
- Influence of spirulina supplementation on growth performance, puberty traits, blood metabolites, testosterone concentrations, and semen quality in Barki male lambs.Open veterinary journal · 2023Article
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- Methotrexate conjugated gold nanoparticles improve rheumatoid vascular dysfunction in rat adjuvant-induced arthritis: gold revival.Inflammopharmacology · 2023Article
- The effects of Phycocyanobilin on experimental arthritis involve the reduction in nociception and synovial neutrophil infiltration, inhibition of cytokine production, and modulation of the neuronal proteome.Frontiers in immunology · 2023Article
- Effects of different levels of spirulina (Arthrospira platensis) supplementation on productive performance, nutrient digestibility, blood metabolites, and meat quality of growing Najdi lambs.Tropical animal health and production · 2022Article
- The effect ofFood science & nutrition · 2022Article
- Protective Effects ofNutrients · 2022Article
- Marine cyanobacterium Spirulina maxima as an alternate to the animal cell culture medium supplement.Scientific reports · 2021Article
- Spirulina platensis extract addition to semen extender enhances cryotolerance and fertilizing potentials of buffalo bull spermatozoa.Animal reproduction · 2021Article
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- Cultivation of Microalgae and Cyanobacteria: Effect of Operating Conditions on Growth and Biomass Composition.Molecules (Basel, Switzerland) · 2020Article
- Lactic Acid Fermentation ofFrontiers in microbiology · 2020Article
- Microwave-Assisted Extraction Combined with In-Capillary [Fe(ferrozine)Molecules (Basel, Switzerland) · 2019Article
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- Hepatoprotective and Anti-Inflammatory Activities of theEvidence-based complementary and alternative medicine : eCAM · 2018Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
One of the major mechanisms in the pathogenesis of chronic inflammation is the excessive production of reactive oxygen and reactive nitrogen species, and therefore, oxidative stress. Spirulina (Arthrospira) maxima has marked antioxidant activity in vivo and in vitro, as well as anti-inflammatory activity in certain experimental models, the latter activity being mediated probably by the antioxidant activity of this cyanobacterium. In the present study, chronic inflammation was induced through injection of Freund's complete adjuvant (CFA) in rats treated daily with Spirulina (Arthrospira) maxima for 2 weeks beginning on day 14. Joint diameter, body temperature, and motor capacity were assessed each week. On days 0 and 28, total and differential leukocyte counts and serum oxidative damage were determined, the latter by assessing lipid peroxidation and protein carbonyl content. At the end of the study, oxidative damage to joints was likewise evaluated. Results show that S. maxima favors increased mobility, as well as body temperature regulation, and a number of circulating leukocytes, lymphocytes, and monocytes in specimens with CFA-induced chronic inflammation and also protects against oxidative damage in joint tissue as well as serum. In conclusion, the protection afforded by S. maxima against development of chronic inflammation is due to its antioxidant activity.
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Registered trials
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