Evidence map›Paper›PMID 25599031›Full record

ArticleInternational journal of pharmaceutical investigation

Evaluation of the efficacy of 2% Ocimum sanctum gel in the treatment of experimental periodontitis.

Rajesh Ramesh Hosadurga, Sudarshan Narayan Rao, Rejeesh Edavanputhalath, Jobin Jose, Narayana Charyulu Rompicharla, Moidin Shakil, Shashidhara Raju

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pharmaceutical investigation. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Review
  3. Medicinal Plants Used as an Alternative to Treat Gingivitis and Periodontitis.Evidence-based complementary and alternative medicine : eCAM · 2022
    Review
  4. Review
  5. Article
  6. Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Rajesh Ramesh HosadurgaDepartment of Periodontics, Yenepoya Dental College, Mangalore, India.
Sudarshan Narayan RaoDepartment of Pharmacology, Yenepoya University, Mangalore, India.
Rejeesh EdavanputhalathDepartment of Pharmacology, Yenepoya University, Mangalore, India.
Jobin JoseDepartment of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Mangalore, India.
Narayana Charyulu RompicharlaDepartment of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Mangalore, India.
Moidin ShakilDepartment of Oral and Maxillofacial Pathology, Yenepoya Dental College, Mangalore, India.
Shashidhara RajuDepartment of Oral and Maxillofacial Pathology, Coorg Institute of Dental Sciences, Karnataka, India.
Yenepoya University · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionOne of the options for the treatment of periodontitis is local drug delivery systems (LDD). Tulsi (Ocimum sanctum), a traditional herb, has many uses in medicine. It could be a suitable agent as LDD for the treatment of periodontitis.

aimThe aim was to formulate, evaluate the anti-inflammatory activity; assess duration of the action and the efficacy of 2% tulsi (O. sanctum) gel in the treatment of experimental periodontitis in Wistar Albino rat model. SETTINGS AND

designThirty six Wistar albino rats were randomly assigned to 3 groups. Periodontitis was induced using ligature model. Group 1-control; Group 2-Plain gel and Group 3-2% tulsi (O. sanctum) gel. MATERIALS AND

methods2% tulsi (O. sanctum) gel were prepared. The anti-inflammatory activity and duration of action were assessed. Silk ligature 5-0 was used to induce periodontitis. Gingival index (GI) and probing pocket depth were measured. Treatment was done. The rats were sacrificed. Morphometric analysis was done using Stereomicroscope and ImageJ software. STATISTICAL ANALYSIS USED: ANOVA followed by Bonferroni's test, Wilcoxon's test for intergroup comparison, Mann-Whitney test for P value computation was used. The observations are mean ± standard deviation and standard error of the mean. P < 0.01 as compared to control was considered as statistically significant.

results2% tulsi (O. sanctum) gel showed 33.66% inhibition of edema and peak activity was noted at 24 h. There was statistically significant change in the GI and probing pocket depth. Morphometric analysis did not show any significant difference between groups. No toxic effects were seen on oral administration of 2000 mg/kg of Tulsi extract.

conclusions2% tulsi (O. sanctum) gel was effective in the treatment of experimental periodontitis.

Indexed as

Anti-inflammatory activityexperimental periodontitislocal drug deliverymorphometric analysistulsi gel

Identifiers

PMID25599031
PMCPMC4286833
OpenAlexW2154488691

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.