Evidence map›Paper›PMID 25599021›Full record

ArticleTranslational cancer research2013

Molecular mechanisms involved in tumor repopulation after radiotherapy.

Wooi-Loon Ng, Qian Huang, Xinjian Liu, Mary Zimmerman, Fang Li, Chuan-Yuan Li

Abstract read
In one paragraph

Article in Translational cancer research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 31 citations in OpenAlex.

  1. Review
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  7. The constructive function of apoptosis: More than a dead-end job.Frontiers in cell and developmental biology · 2022
    Article
  8. Review
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  11. Review
  12. Hypoxia imaging withRadiation oncology (London, England) · 2018
    Article
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Wooi-Loon NgDepartment of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.
Qian HuangDepartment of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.
Xinjian LiuDepartment of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.
Mary ZimmermanDepartment of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.
Fang LiDepartment of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.
Chuan-Yuan LiDepartment of Dermatology, Duke University Medical Center, Durham, NC 27710, USA.
Duke University Hospital · USDuke Medical Center · US

Funding

The "Phoenix Rising" pathway of tumor repopulation during radiotherapyR01CA155270 · NCI · DUKE UNIVERSITY · PI LI, CHUAN-YUAN · 2011 to 2015
$1.6M
Molecular mechanisms of tumor response to cytotoxic chemotherapyR01CA136748 · NCI · UNIVERSITY OF COLORADO DENVER · PI LI, CHUAN-YUAN · 2009 to 2014
$1.5M
HIF genes in head and neck cancer radiotherapyR01CA131408 · NCI · UNIVERSITY OF COLORADO DENVER · PI LI, CHUAN-YUAN · 2009 to 2014
$1.5M
NCI NIH HHS R01 CA131408NCI NIH HHS R01 CA136748NCI NIH HHS R01 CA155270
6 · The paper itself

Abstract

Radiotherapy remains one of most important treatment modalities for solid tumors. Current radiotherapy is mostly based on a set of concepts called the 4"R"s, which were established when there was lack of understanding of the underlying molecular mechanisms. However, progress made in the past two decades are beginning to allow us to see some of the molecular details involved in tumor response to radiation therapy. In this review, we will attempt to summarize some of the key discoveries in molecular radiation biology that have direct relevance to radiotherapy. We will focus our discussion on areas such as radiation induced tumor vasculogenesis, stem cell mobilization, and cellular repopulation. We hope our discussion will stimulate further studies in this important area of cancer research.

Indexed as

4“R”sphoenix rising pathwayRadiation therapytumor repopulationvasculogenesis

Identifiers

PMID25599021
PMCPMC4293635
OpenAlexW2147320765

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.