Evidence map›Paper›PMID 25599005›Full record

ArticleCurrent protocols in mouse biology

Current Protocols in Mouse Biology.

Casey R Doucette, Clifford J Rosen

Abstract read
In one paragraph

Article in Current protocols in mouse biology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Casey R DoucetteMaine Medical Center Research Institute, 81 Research Drive, Scarborough ME 04074, Tel: (207) 396-8003, casey.doucette@maine.edu.
Clifford J RosenMaine Medical Center Research Institute, 81 Research Drive, Scarborough ME 04074, Tel: (207) 396-8228, , crofen@gmail.com.
Maine Medical Center Research Institute · US

Funding

Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0M
Misty: a model for central regulation of bone remodelingR01AG040217 · NIA · MAINEHEALTH · PI ROSEN, CLIFFORD JAMES · 2011 to 2015
$1.7M
Interdisciplinary study of marrow adiposity, mineral metabolism,and energy balancR24DK084970 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, KLIBANSKI, ANNE · 2010 to 2010
$501k
NIA NIH HHS R01 AG040217NIDDK NIH HHS R24 DK084970NIDDK NIH HHS R24 DK092759
6 · The paper itself

Abstract

Bone is an essential organ that not only confers structural stability to the organism, but also serves as a reservoir for hematopoietic elements and is thought to affect systemic homeostasis through the release of endocrine factors as well as calcium. The loss of bone mass due to an uncoupling of bone formation and bone resorption leads to increased fragility that can result in devastating fractures. Further understanding of the effects of environmental stimuli on the development of bone disease in humans is needed, and can be studied using animal models. In this chapter, we present established and novel methods for the induction of bone loss in mice, including manipulation of diet and environment, drug administration, irradiation, and hormone deficiency. All of these models are directly related to human cases, and can thus be used to investigate the causes of bone loss resulting from these interventions.

Indexed as

Bone losscalorie restrictioncold exposurehigh fat dietirradiationmouse modelsovariectomyrosiglitazone

Identifiers

PMID25599005
PMCPMC4295777
OpenAlexW1568225933

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.