ArticleOrthopedic & muscular system : current research
The Roles of Small GTPases in Osteoclast Biology.
Article in Orthopedic & muscular system : current research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 37 citations in OpenAlex.
- Rac1-dependent regulation of osteoclast and osteoblast differentiation by developmentally regulated GTP-binding 2.Cell death discovery · 2025Article
- Impact of substrate choice on human osteoclast differentiation and secretome: Implications for targeted therapeutic development.PloS one · 2025Article
- Trachelogenin alleviates osteoarthritis by inhibiting osteoclastogenesis and enhancing chondrocyte survival.Chinese medicine · 2024Article
- Unraveling the intricacies of osteoclast differentiation and maturation: insight into novel therapeutic strategies for bone-destructive diseases.Experimental & molecular medicine · 2024Review
- A Zeb1/MtCK1 metabolic axis controls osteoclast activation and skeletal remodeling.The EMBO journal · 2023Article
- Ras family signaling pathway in immunopathogenesis of inflammatory rheumatic diseases.Frontiers in immunology · 2023Review
- Ras and Rab Interactor 3: From Cellular Mechanisms to Human Diseases.Frontiers in cell and developmental biology · 2022Review
- AnJBMR plus · 2021Article
- Osteoclast fusion and bone loss are restricted by interferon inducible guanylate binding proteins.Nature communications · 2021Article
- The Role of Osteoclast Energy Metabolism in the Occurrence and Development of Osteoporosis.Frontiers in endocrinology · 2021Review
- Membrane Transport Proteins in Osteoclasts: The Ins and Outs.Frontiers in cell and developmental biology · 2021Review
- Reduced CpG island methylation of the TBC1D8 gene may predict risk for osteoporosis in Chinese postmenopausal women.Oncotarget · 2020Article
- Cytoplasmic PCNA is located in the actin belt and involved in osteoclast differentiation.Aging · 2020Article
- Relationship Between Metabolic Syndrome and Bone Health - An Evaluation of Epidemiological Studies and Mechanisms Involved.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Review
- Activin A receptor type 1-mediated BMP signaling regulates RANKL-induced osteoclastogenesis via canonical SMAD-signaling pathway.The Journal of biological chemistry · 2019Article
- Bone morphogenetic proteins: Their role in regulating osteoclast differentiation.Bone reports · 2019Review
- Signaling mechanisms and physiological functions of G-protein GαProtein science : a publication of the Protein Society · 2019Review
- Rab GTPases in Osteoclastic Endomembrane Systems.BioMed research international · 2018Review
- Effect of corticision on orthodontic tooth movement in a rat model as assessed by RNA sequencing.Journal of molecular histology · 2017Article
- Def6 Restrains Osteoclastogenesis and Inflammatory Bone Resorption.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The adult skeleton undergoes bone remodeling that consists of bone formation by osteoblasts and bone resorption by osteoclasts. When the amount of bone resorbed is greater than the amount of new bone formed, low bone mass results, putting individuals at increased risk for osteoporosis and osteoporotic bone fracture. Nitrogenous bisphosphonates (NBPs) are the most common first line treatment for conditions of low bone mass. NBPs reduce osteoclast bone resorption by impairing the post-translational modification of small GTPases. Small GTPases play crucial roles in the differentiation, function, and survival of osteoclasts. Understanding the roles of individual small GTPases in osteoclast biology may lead to more targeted therapies for the treatment of low bone mass. In this review, we discuss recent investigations into the
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.