ArticleIranian endodontic journal2015
Toxicity of calcium hydroxide nanoparticles on murine fibroblast cell line.
Article in Iranian endodontic journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed.
- The antibacterial effect and the incidence of post-operative pain after the application of nano-based intracanal medications during endodontic retreatment: a randomized controlled clinical trial.Clinical oral investigations · 2022Trial
- Improvement of Dentin Growth Parameters (Beta-catenin, bFGF, CD105, and BMP4) with Propolis as Adjuvant in Dental Caries Treatment.European journal of dentistry · 2025Article
- Cytotoxicity of Different Concentrations of Silver Nanoparticles and Calcium Hydroxide for MC3T3-E1 Preosteoblast Cell Line.Clinical and experimental dental research · 2025Article
- The viability of human dental pulp cells and apical papilla cells after treatment with conventional calcium hydroxide and nanoparticulate calcium hydroxide at various concentrations.The Saudi dental journal · 2023Article
- Antimicrobial Effect of Nano-Calcium Hydroxide on the Four- and Six-Week-Old Intra-CanalJournal of dentistry (Shiraz, Iran) · 2023Article
- Application of Inorganic Nanomaterials in Cultural Heritage Conservation, Risk of Toxicity, and Preventive Measures.Nanomaterials (Basel, Switzerland) · 2023Review
- Enzyme-Mediated Alleviation of Peroxide Toxicity in Self-Oxygenating Biomaterials.Advanced healthcare materials · 2022Article
- Article
- The Potential Translational Applications of Nanoparticles in Endodontics.International journal of nanomedicine · 2021Review
- Combinations of propolis and Ca(OH)2 in dental pulp capping treatment for the stimulation of reparative dentin formation in a rat model.F1000Research · 2020Article
- Cytotoxicity and Effects of a New Cacium Hydroxide Nanoparticle Material on Production of Reactive Oxygen Species by LPS-Stimulated Dental Pulp Cells.Iranian endodontic journal · 2020Article
- Subcutaneous Connective Tissue Reaction to a New Nano Zinc-Oxide Eugenol Sealer in Rat Model.Iranian endodontic journal · 2017Article
- Surgical Treatment of an Immature Short-Rooted Traumatized Incisor with an Extensive Apical Lesion Using CEM Cement.Iranian endodontic journal · 2015Article
- Cytotoxicity of a New Nano Zinc-Oxide Eugenol Sealer on Murine Fibroblasts.Iranian endodontic journal · 2015Article
- Cytotoxicity of oregano essential oil and calcium hydroxide on L929 fibroblast cell: A molecular level study.Journal of conservative dentistry : JCDArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionOne of the major contributing factors, which may cause failure of endodontic treatment, is the presence of residual microorganisms in the root canal system. For years, most dentists have been using calcium hydroxide (CH) as the intracanal medicament between treatment sessions to eliminate remnant microorganisms. Reducing the size of CH particles into nanoparticles enhances the penetration of this medicament into dentinal tubules and increases their antimicrobial efficacy. This in vitro study aimed to compare the cytotoxicity of CH nanoparticles and conventional CH on fibroblast cell line using the Mosmann's Tetrazolium Toxicity (MTT) assay. METHODS AND MATERIALS: This study was conducted on L929 murine fibroblast cell line by cell culture and evaluation of the direct effect of materials on the cultured cells. Materials were evaluated in two groups of 10 samples each at 24, 48 and 72 h. At each time point, 10 samples along with 5 positive and 5 negative controls were evaluated. The samples were transferred into tubes and exposed to fibroblast cells. The viability of cells was then evaluated. The Two-way ANOVA was used for statistical analysis and the level of significance was set at 0.05.
resultsCytotoxicity of both materials decreased over time and for conventional CH was lower than that of nanoparticles. However, this difference was not statistically significant (P>0.05).
conclusionThe cytotoxicity of CH nanoparticles was similar to that of conventional CH.
Indexed as
Identifiers
25598810PMC4293581What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.