Evidence map›Paper›PMID 25598765›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society

Metabonomics of human fecal extracts characterize ulcerative colitis, Crohn's disease and healthy individuals.

Jacob Tveiten Bjerrum, Yulan Wang, Fuhua Hao, Mehmet Coskun, Christian Ludwig, Ulrich Günther, Ole Haagen Nielsen

2 registry-linked trialsOpen access · hybridAbstract read
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 118 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
118citing papers in PubMed, 3 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02796339 phase2completednot on this map

A Phase-II Clinical Trial on the Effectiveness of a Nutritional Supplement With Natural Mastiha in Inflammatory Bowel Diseases Patients.

TypeinterventionalSponsorHarokopio UniversityRan2016 to 2021Enrolled100ConditionsInflammatory Bowel DiseasesArmsMastiha, Placebo
NCT04630782 unknown statusnot on this map

Precision Medicine in Systemic Sclerosis Gastrointestinal Disease: Evaluating Imaging and Stool Biomarkers for Differentiating Disease Stages and Treatment Responses

TypeobservationalSponsorSingapore General HospitalRan2020 to 2023Enrolled70ConditionsSystemic Sclerosis, SclerodermaArmsPET-MRI scan
3 · Its place in the literature

Who cites it

118 citing papers in PubMed, 3 syntheses or guidelines pooled it, 247 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Effects of pentasa-combined probiotics on the microflora structure and prognosis of patients with inflammatory bowel disease.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019
    Trial
  5. Trial
  6. Review
  7. Review
  8. Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

58 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 3 countries.

Jacob Tveiten BjerrumDepartment of Cellular and Molecular Medicine, The Panum Institute, University of Copenhagen, Copenhagen, Denmark ; Department of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Yulan WangKey Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan, People's Republic of China ; Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, People's Republic of China.
Fuhua HaoKey Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Centre for Magnetic Resonance, Wuhan Institute of Physics and Mathematics, The Chinese Academy of Sciences, Wuhan, People's Republic of China.
Mehmet CoskunDepartment of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Christian LudwigHWB-NMR, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
Ulrich GüntherHWB-NMR, School of Cancer Sciences, University of Birmingham, Edgbaston, Birmingham, UK.
Ole Haagen NielsenDepartment of Gastroenterology, Medical Section, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Chinese Academy of Sciences · CNHerlev Hospital · DKUniversity of Birmingham · GBUniversity of Copenhagen · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study employs spectroscopy-based metabolic profiling of fecal extracts from healthy subjects and patients with active or inactive ulcerative colitis (UC) and Crohn's disease (CD) to substantiate the potential use of spectroscopy as a non-invasive diagnostic tool and to characterize the fecal metabolome in inflammatory bowel disease (IBD). Stool samples from 113 individuals (UC 48, CD 44, controls 21) were analyzed by

Indexed as

Diagnostic toolDysbiosisInflammatory bowel diseaseMetabolomicsNMR spectroscopy

Identifiers

PMID25598765
PMCPMC4289537
OpenAlexW2043773237

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.