ArticleMetabolomics : Official journal of the Metabolomic Society
Molecular phenotyping of a UK population: defining the human serum metabolome.
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Article in Metabolomics : Official journal of the Metabolomic Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers, 1 of them a synthesis that pooled it.
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121citing papers in PubMed, 1 pooled it
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121 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomics facilitates the discovery of metabolic biomarkers and pathways for ischemic stroke: a systematic review.Metabolomics : Official journal of the Metabolomic Society · 2019Pooled it
- Age and sex are associated with the plasma lipidome: findings from the GOLDN study.Lipids in health and disease · 2021Trial
- Effect of dietary sodium restriction on human urinary metabolomic profiles.Clinical journal of the American Society of Nephrology : CJASN · 2015Trial
- Classifying smoking status using linear and non-linear models based on clinical health records.Analytical and bioanalytical chemistry · 2026Article
- Amino acid-based biological age clock and its implications for human health and aging.Nature communications · 2026Article
- Metabolomics and Human Health: Progress, Insights, Challenges and the Concept of a Healthy Metabolome.Biomolecules · 2026Review
- Metabolomics biomarkers for precision psychiatry.Frontiers in psychiatry · 2026Review
- Toward Precision Medicine in Atherosclerotic Cardiovascular Disease: Insights from Omics Data into Sex Differences.Current atherosclerosis reports · 2025Review
- Sex Modifies Metabolic Pathways Associated with Lipids in Untargeted Metabolomics: The Coronary Artery Risk Development in Young Adults (CARDIA) Study, 2005-2006.Metabolites · 2025Article
- Age-related microbiome metabolites alter RNA splicing and chromatin accessibility in the brain.bioRxiv : the preprint server for biology · 2025Article
- Combining clinical chemistry with metabolomics for metabolic phenotyping at population levels.Metabolomics : Official journal of the Metabolomic Society · 2025Article
- Breath and Blood Metabolomics: A Comparative Study Using SESI-HRMS/MS and UHPLC-ESI-HRMS/MS.Environment & health (Washington, D.C.) · 2025Article
- Metabolomics biomarkers of frailty: a longitudinal study of aging female and male mice.npj aging · 2025Article
- Metabolism and metabolomics in senescence, aging, and age-related diseases: a multiscale perspective.Frontiers of medicine · 2025Review
- The prowess of metabolomics in cancer research: current trends, challenges and future perspectives.Molecular and cellular biochemistry · 2025Review
- Detection and quantification of ergothioneine in human serum using surface enhanced Raman scattering (SERS).The Analyst · 2025Article
- Global Metabolomics Using LC-MS for Clinical Applications.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Animal models in tuberculosis metabolomics: a systematic review of current evidence and the road to translational relevance.Frontiers in molecular biosciences · 2025Review
- Metabolomic heterogeneity of ageing with ethnic diversity: a step closer to healthy ageing.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- A Reproducibility Crisis for Clinical Metabolomics Studies.Trends in analytical chemistry : TRAC · 2024Article
61 more citing papers are in PubMed but not listed here.
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Authors and funding
36 authors.
Warwick B DunnFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; Faculty of Engineering & Physical Sciences, Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; Faculty of Medical and Human Sciences, Centre for Endocrinology and Diabetes, Institute of Human Development, The University of Manchester, Manchester, UK ; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, M13 9WL UK ; School of Biosciences, University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Wanchang LinFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; Faculty of Medical and Human Sciences, Centre for Endocrinology and Diabetes, Institute of Human Development, The University of Manchester, Manchester, UK ; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, M13 9WL UK.
David BroadhurstFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; Department of Medicine, Katz Group Centre for Pharmacy & Health, University of Alberta, Edmonton, AB T6G 2R3 Canada.
Paul BegleyFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; Faculty of Medical and Human Sciences, Centre for Endocrinology and Diabetes, Institute of Human Development, The University of Manchester, Manchester, UK ; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, M13 9WL UK.
Marie BrownFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; Faculty of Medical and Human Sciences, Centre for Endocrinology and Diabetes, Institute of Human Development, The University of Manchester, Manchester, UK ; Centre for Advanced Discovery and Experimental Therapeutics (CADET), Central Manchester University Hospitals NHS Foundation Trust, Manchester Academic Health Sciences Centre, Manchester, M13 9WL UK.
Eva ZelenaFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Andrew A VaughanFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Antony HalsallFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Nadine HardingFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Joshua D KnowlesFaculty of Engineering & Physical Sciences, School of Computer Science, The University of Manchester, Manchester, M13 9PL UK.
Sue Francis-McIntyreFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Andy TsengFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
David I EllisFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Steve O'HaganFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Gill AaronsFaculty of Medical & Human Sciences, Institute of Inflammation and Repair, Salford Royal Dermatopharmacology, The University of Manchester, Manchester, M6 8HD UK.
Boben BenjaminClinical & Cognitive Neurosciences, Faculty of Medical & Human Sciences, Institute of Brain, Behaviour & Mental Health, The University of Manchester, Manchester, M13 9PT UK.
Stephen Chew-GrahamClinical & Cognitive Neurosciences, Faculty of Medical & Human Sciences, Institute of Brain, Behaviour & Mental Health, The University of Manchester, Manchester, M13 9PT UK.
Carly MoseleyFaculty of Medical and Human Sciences, Institute of Cancer Sciences, Christie Hospital, The University of Manchester, Manchester, M20 4BX UK.
Paula PotterFaculty of Medical and Human Sciences, Institute of Cancer Sciences, Christie Hospital, The University of Manchester, Manchester, M20 4BX UK.
Catherine L WinderFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; Faculty of Engineering & Physical Sciences, Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Catherine PottsFaculty of Medical & Human Sciences, Institute of Human Development, The University of Manchester, Manchester, M13 9WL UK.
Paula ThorntonFaculty of Medical and Human Sciences, Institute of Cancer Sciences, Christie Hospital, The University of Manchester, Manchester, M20 4BX UK.
Catriona McWhirterFaculty of Medical & Human Sciences, Institute of Human Development, The University of Manchester, Manchester, M13 9WL UK.
Mohammed ZubairClinical & Cognitive Neurosciences, Faculty of Medical & Human Sciences, Institute of Brain, Behaviour & Mental Health, The University of Manchester, Manchester, M13 9PT UK.
Martin PanNeurology and Gastrointestinal Centre of Excellence for Drug Discovery, GlaxoSmithKline, Third Avenue, Harlow, Essex, CM19 5AW UK.
Alistair BurnsClinical & Cognitive Neurosciences, Faculty of Medical & Human Sciences, Institute of Brain, Behaviour & Mental Health, The University of Manchester, Manchester, M13 9PT UK.
J Kennedy CruickshankFaculty of Medical & Human Sciences, Institute of Cardiovascular Sciences, The University of Manchester, Manchester, M13 9PT UK ; St Thomas' Hospital, King's College, University of London & King's Health Partners, London, SE1 9NH UK.
Gordon C JaysonFaculty of Medical and Human Sciences, Institute of Cancer Sciences, Christie Hospital, The University of Manchester, Manchester, M20 4BX UK.
Nitin PurandareFaculty of Medical & Human Sciences, Institute of Cardiovascular Sciences, The University of Manchester, Manchester, M13 9PT UK.
Frederick C W WuFaculty of Medical & Human Sciences, Institute of Human Development, The University of Manchester, Manchester, M13 9WL UK.
Joe D FinnFaculty of Medical & Human Sciences, Institute of Human Development, The University of Manchester, Manchester, M13 9WL UK.
John N HaseldenInvestigative Preclinical Toxicology, GlaxoSmithKline, David Jack Centre for Research and Development, Park Road, Ware, Hertfordshire, SG12 0DP UK.
Andrew W NichollsInvestigative Preclinical Toxicology, GlaxoSmithKline, David Jack Centre for Research and Development, Park Road, Ware, Hertfordshire, SG12 0DP UK.
Ian D WilsonFaculty of Medicine, Department of Surgery & Cancer, Sir Alexander Fleming Building, Imperial College London, London, SW7 2AZ, UK ; DMPK Innovative Medicines, AstraZeneca, Cheshire, SK10 4TF UK.
Royston GoodacreFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; Faculty of Engineering & Physical Sciences, Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Douglas B KellFaculty of Engineering and Physical Sciences, School of Chemistry, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK ; Faculty of Engineering & Physical Sciences, Manchester Centre for Integrative Systems Biology, Manchester Institute of Biotechnology, The University of Manchester, Manchester, M1 7DN UK.
Funding
Biotechnology and Biological Sciences Research Council BB/C51902X/1Biotechnology and Biological Sciences Research Council BB/C519038/1Medical Research Council MC_QA137293
Abstract
Phenotyping of 1,200 'healthy' adults from the UK has been performed through the investigation of diverse classes of hydrophilic and lipophilic metabolites present in serum by applying a series of chromatography-mass spectrometry platforms. These data were made robust to instrumental drift by numerical correction; this was prerequisite to allow detection of subtle metabolic differences. The variation in observed metabolite relative concentrations between the 1,200 subjects ranged from less than 5 % to more than 200 %. Variations in metabolites could be related to differences in gender, age, BMI, blood pressure, and smoking. Investigations suggest that a sample size of 600 subjects is both necessary and sufficient for robust analysis of these data. Overall, this is a large scale and non-targeted chromatographic MS-based metabolomics study, using samples from over 1,000 individuals, to provide a comprehensive measurement of their serum metabolomes. This work provides an important baseline or reference dataset for understanding the 'normal' relative concentrations and variation in the human serum metabolome. These may be related to our increasing knowledge of the human metabolic network map. Information on the Husermet study is available at http://www.husermet.org/. Importantly, all of the data are made freely available at MetaboLights (http://www.ebi.ac.uk/metabolights/).
Indexed as
Clinical biochemistryHuman serumMass spectrometryMetabolic phenotypingUK population
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