ArticleInternational journal of biomedical science : IJBS2014
Relationship between Glycosylated Hemoglobin, Serum Nitric Oxide and Mean Arterial Blood Pressure.
Article in International journal of biomedical science : IJBS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
3 citing papers in PubMed.
- Systemic nitric oxide metabolites and the chance of pre-diabetes regression to normoglycemia: A 9-year cohort study.BioImpacts : BI · 2024Article
- Nitric oxide and TNF-α are correlates of diabetic retinopathy independent of hs-CRP and HbA1c.Endocrine · 2020Article
- HbA1c may contribute to the development of non-alcoholic fatty liver disease even at normal-range levels.Bioscience reports · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension is about twice as frequent in individuals with diabetes as in those without diabetes. Formation of glycosylated conjugates like HbA1c is implicated to have many effects on the vascular endothelium which leads to the development of hypertension in diabetes. Nitric oxide (NO)-dependent vasodilatation has been shown to be an important factor in the maintenance and regulation of peripheral vascular tone. Studies correlating these parameters give conflicting results. Hence the present study was designed to correlate HbA1c, Serum NO & mean arterial blood pressure.
aimsTo study the relationship between glycosylated hemoglobin, serum nitric oxide & mean arterial blood pressure. SETTINGS AND
designIt is a case control study with 28 type 2 diabetic hypertensives, 32 type 2 diabetic normotensives and 51 controls (non diabetic normotensives). MATERIALS &
methodsThe study subjects included 28 type 2 diabetic hypertensives, 32 type 2 diabetic normotensives and 51 controls (non diabetic normotensives) [ADA 2010 and JNC7]. FBS, PPBS, PCV, Hb, HbA1c & serum NO estimation and BP recording was done in all the study subjects. Normalised mean arterial blood pressure (MAPn) and calculated glycosylated hemoglobin (cHbA1c) were calculated from mean arterial BP (MAP) and HbA1c respectively. STATISTICAL ANALYSIS: was done using R commander software. The difference in the distribution of cHbA1c, MAPn & NO levels between all 3 groups was measured using ANOVA and Kruskal-Wallis test. Correlation between the parameters was measured by Correlation coefficient and logistic regression (Spearman linear regression) analysis (univariate and multivariate).
resultsThere was a significant difference in the distribution of cHbA1c, MAPn & NO levels (p<0.001) between all 3 groups, whether measured by ANOVA or Kruskal-Wallis test. On univariate analysis, there was a positive correlation between cHbA1c & MAPn (ρ= +0.26), a negative correlation between NO & MAPn (ρ = -0.54) and cHbA1c & NO (ρ= -0.66) .On multivariate analysis, not only NO, but contrary to univariate analysis, cHbA1c also showed a negative association with MAPn.
conclusionAs the severity of diabetes increases, there is increase in BP, which is mainly due to the marked decrease in NO level which masks the negative correlation between HbA1c on MAPn.
Indexed as
Identifiers
25598756PMC4289699What OpenQuestion holds
Registered trials
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