ArticlePharmacognosy research
Isolation, structural characterization and in silico drug-like properties prediction of a natural compound from the ethanolic extract of Cayratia trifolia (L.).
Article in Pharmacognosy research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Characterization of the Biological Activity of the Ethanolic Extract from the Roots ofAntioxidants (Basel, Switzerland) · 2022Article
- (5E,7E)-4,5,6 Trihydroxy-3-(hydroxymethyl)tetrahydro-2H-pyran-2-ylheptadeca-5,7-dienoate fromBioinorganic chemistry and applications · 2022Article
- Molecular docking analysis of mTOR protein kinase with chromatographically characterized compounds fromBioinformation · 2022Article
- Yield, Characterization, and Possible Exploitation ofMolecules (Basel, Switzerland) · 2021Article
- Chemotherapeutic potential of Cayratia trifolia L nhexane extract on A2780 cells.Bioinformation · 2021Article
- Antioxidant, antimicrobial and cytotoxicity potential of n-hexane extract of Cayratia trifolia L.Bioinformation · 2021Article
- Anti-ovarian cancer potential of phytocompound and extract from South African medicinal plants and their role in the development of chemotherapeutic agents.American journal of cancer research · 2021Review
- Molecular docking and GC-MS data for the inhibition of RAD51 expression by a compound from Clerodendrum inerme L.Bioinformation · 2021Article
- Screening and GC-MS profiling of ethanolic extract ofBioinformation · 2019Article
- Biochemical and molecular analysis ofJournal, genetic engineering & biotechnology · 2016Article
- Screening of Potential Phytocompounds FromJournal of pharmacy & bioallied sciencesArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNatural products have continually played an important role in drug discovery because it serves as active principles in drugs as well as templates for synthesis of new drugs. Cayratia trifolia (L.) is a medicinal plant, which has been reported to have antiviral, antibacterial, antiprotozoal, hypoglycemic, anticancer and diuretic activities.
objectiveTherefore, the objective of this study is to isolate and identify the natural compound from the ethanolic extract of Cayratia trifolia (L.) and to predict the Absorption, Distribution, Metabolism and Excretion (ADME) properties of isolated natural compound. MATERIALS AND
methodsColumn chromatography and thin layer chromatography were used to isolate the natural compound and Fourier-transform infrared (FTIR) spectroscopy was used to predict the functional groups present in the isolated natural compound. The structural characterization studies were functionally carried out using (1)H, (13)C, two-dimensional nuclear magnetic resonance (NMR) and mass spectrometry methods.
resultsFTIR showed that, the groups of OH, C-H, C = C may be present in the isolated natural compound. (1)H, (13)C, two-dimensional NMR and mass spectrometry data suggests that the isolated natural compound probably like linoleic acid. In silico ADME properties, prediction of the compound was under acceptable range.
conclusionBased on the results, it can be concluded that, the isolated natural compound of linoleic acid that has been exhibited good medicinal properties.
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