Evidence map›Paper›PMID 25598343›Full record

ArticleScientific reports2015

Effect of knocking down the insulin receptor on mouse rod responses.

Michael L Woodruff, Ammaji Rajala, Gordon L Fain, Raju V S Rajala

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
  3. The Mechanism of Phillyrin from the Leaves ofBioMed research international · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Michael L WoodruffDepartment of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, 90095-7239.
Ammaji RajalaDepartment of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.
Gordon L Fain1] Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, 90095-7239 [2] Department of Ophthalmology and Jules Stein Eye Institute, University of California Los Angeles, Los Angeles, California, 90095-7000.
Raju V S Rajala1] Department of Ophthalmology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104 [2] Department of Physiology and University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104 [3] Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104.
University of California, Los Angeles · USUniversity of Oklahoma Health Sciences Center · US

Funding

Vision Research Core at UCLAP30EY000331 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Xian-Jie Yang · 1985 to 2026
$16.8M
PHYSIOLOGY OF PHOTORECEPTORSR01EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI GORDON Lee FAIN · 1985 to 2026
$9.9M
SECOND MESSENGERS IN THE RETINAR01EY000871 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RAJALA, RAJU VS · 1985 to 2020
$7.2M
Light Activation of Retinal Insulin Receptor SignalingR01EY016507 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI RAJALA, RAJU VS · 2006 to 2013
$2.7M
PHYSIOLOGY OF PHOTORECEPTORSR37EY001844 · NEI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI FAIN, GORDON LEE · 1990 to 1999
–
NEI NIH HHS EY00871NEI NIH HHS EY016507NEI NIH HHS EY01844NEI NIH HHS P30 EY000331NEI NIH HHS R01 EY000871NEI NIH HHS R01 EY001844NEI NIH HHS R01 EY016507NEI NIH HHS R37 EY001844
6 · The paper itself

Abstract

Previous experiments have shown that the insulin receptor (IR) is expressed in mammalian rods and contributes to the protection of photoreceptors during bright-light exposure. The role of the insulin receptor in the production of the light response is however unknown. We have used suction-electrode recording to examine the responses of rods after conditionally knocking down the insulin receptor. Our results show that these IR knock-down rods have an accelerated decay of the light response and a small decrease in sensitivity by comparison to littermate WT rods. Our results indicate that the insulin receptor may have some role in controlling the rate of rod response decay, but they exclude a major role of the insulin receptor pathway in phototransduction.

Indexed as

AnimalsLightMiceMice, KnockoutPhotic StimulationPhotoreceptor CellsReceptor, InsulinRetinal Rod Photoreceptor CellsReceptor, Insulin

Identifiers

PMID25598343
PMCPMC4297982
OpenAlexW2061490855

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.