Evidence map›Paper›PMID 25598302›Full record

ArticleScientific reports2015

A closer look at the apparent correlation of structural and functional connectivity in excitable neural networks.

Arnaud Messé, Marc-Thorsten Hütt, Peter König, Claus C Hilgetag

Abstract read
In one paragraph

Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
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  7. Article
  8. The brainstem connectome database.Scientific data · 2022
    Article
  9. Article
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  11. Article
  12. Review
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  14. Link-usage asymmetry and collective patterns emerging from rich-club organization of complex networks.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. What We Know About the Brain Structure-Function Relationship.Behavioral sciences (Basel, Switzerland) · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Arnaud MesséDepartment of Computational Neuroscience, University Medical Center Eppendorf, Hamburg University, Germany.
Marc-Thorsten HüttSchool of Engineering and Science, Jacobs University Bremen, Germany.
Peter KönigDepartment of Cognitive Science, University Osnabrück, Germany.
Claus C Hilgetag1] Department of Computational Neuroscience, University Medical Center Eppendorf, Hamburg University, Germany [2] Department of Health Sciences, Boston University, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The relationship between the structural connectivity (SC) and functional connectivity (FC) of neural systems is a central focus in brain network science. It is an open question, however, how strongly the SC-FC relationship depends on specific topological features of brain networks or the models used for describing excitable dynamics. Using a basic model of discrete excitable units that follow a susceptible - excited - refractory dynamic cycle (SER model), we here analyze how functional connectivity is shaped by the topological features of a neural network, in particular its modularity. We compared the results obtained by the SER model with corresponding simulations by another well established dynamic mechanism, the Fitzhugh-Nagumo model, in order to explore general features of the SC-FC relationship. We showed that apparent discrepancies between the results produced by the two models can be resolved by adjusting the time window of integration of co-activations from which the FC is derived, providing a clearer distinction between co-activations and sequential activations. Thus, network modularity appears as an important factor shaping the FC-SC relationship across different dynamic models.

Indexed as

Neural Networks, ComputerAnimalsBrainHumansNerve Net

Identifiers

PMID25598302
PMCPMC4297952

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.