ArticleJournal of neuroscience methods2015
Low-cost blast wave generator for studies of hearing loss and brain injury: blast wave effects in closed spaces.
Article in Journal of neuroscience methods, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- Progression of Vestibular Deficits Following Moderate-Intensity Blast Overpressure in Rats.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Multifunctional redox modulator prevents blast-induced loss of cochlear and vestibular hair cells and auditory spiral ganglion neurons.Scientific reports · 2024Article
- Poly ADP-Ribose Polymerase-1 inhibition by 3-aminobenzamide recuperates HEI-OC1 auditory hair cells from blast overpressure-induced cell death.Frontiers in cell and developmental biology · 2023Article
- Blast trauma affects production and perception of mouse ultrasonic vocalizations.The Journal of the Acoustical Society of America · 2022Article
- Traumatic brain injury induced by exposure to blast overpressure via ear canal.Neural regeneration research · 2022Article
- Unexpected Consequences of Noise-Induced Hearing Loss: Impaired Hippocampal Neurogenesis, Memory, and Stress.Frontiers in integrative neuroscience · 2022Review
- Effect of shock wave power spectrum on the inner ear pathophysiology in blast-induced hearing loss.Scientific reports · 2021Article
- Article
- Evaluation of Patients with Post-Traumatic Hearing Loss: A Retrospective Review of 506 Cases.The journal of international advanced otology · 2021Article
- Long term changes to auditory sensitivity following blast trauma in mice.Hearing research · 2021Article
- Mechanistic Analysis of Age-Related Clinical Manifestations in Down Syndrome.Frontiers in aging neuroscience · 2021Article
- Blast-induced hearing loss suppresses hippocampal neurogenesis and disrupts long term spatial memory.Hearing research · 2020Article
- Noise-induced hearing loss alters hippocampal glucocorticoid receptor expression in rats.Hearing research · 2019Article
- Long-Term Functional and Structural Consequences of Primary Blast Overpressure to the Eye.Journal of neurotrauma · 2018Article
- Presbycusis Disrupts Spontaneous Activity Revealed by Resting-State Functional MRI.Frontiers in behavioral neuroscience · 2018Article
- Noise trauma induced plastic changes in brain regions outside the classical auditory pathway.Neuroscience · 2016Article
- Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
Abstract
backgroundMilitary personnel and civilians living in areas of armed conflict have increased risk of exposure to blast overpressures that can cause significant hearing loss and/or brain injury. The equipment used to simulate comparable blast overpressures in animal models within laboratory settings is typically very large and prohibitively expensive. NEW
methodTo overcome the fiscal and space limitations introduced by previously reported blast wave generators, we developed a compact, low-cost blast wave generator to investigate the effects of blast exposures on the auditory system and brain.
resultsThe blast wave generator was constructed largely from off the shelf components, and reliably produced blasts with peak sound pressures of up to 198dB SPL (159.3kPa) that were qualitatively similar to those produced from muzzle blasts or explosions. Exposure of adult rats to 3 blasts of 188dB peak SPL (50.4kPa) resulted in significant loss of cochlear hair cells, reduced outer hair cell function and a decrease in neurogenesis in the hippocampus. COMPARISON TO EXISTING
methodsExisting blast wave generators are typically large, expensive, and are not commercially available. The blast wave generator reported here provides a low-cost method of generating blast waves in a typical laboratory setting.
conclusionsThis compact blast wave generator provides scientists with a low cost device for investigating the biological mechanisms involved in blast wave injury to the rodent cochlea and brain that may model many of the damaging effects sustained by military personnel and civilians exposed to intense blasts.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.