ArticleMolecular plant pathology2015
Fungal oxalate decarboxylase activity contributes to Sclerotinia sclerotiorum early infection by affecting both compound appressoria development and function.
Article in Molecular plant pathology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Decarboxylase mediated oxalic acid metabolism is important to antioxidation and detoxification rather than pathogenicity inVirulence · 2025Article
- The Velvet Complex Is Essential for Sclerotia Formation and Virulence inJournal of fungi (Basel, Switzerland) · 2025Article
- Autophagy-Related Proteins (ATGs) Are Differentially Required for Development and Virulence ofJournal of fungi (Basel, Switzerland) · 2025Article
- Functional diversification of oxalate decarboxylases in terms of enzymatic activity, morphosporogenesis, stress regulation and virulence inFrontiers in microbiology · 2025Article
- Role of oxalic acid in fungal and bacterial metabolism and its biotechnological potential.World journal of microbiology & biotechnology · 2024Review
- The Effects of Antofine on the Morphological and Physiological Characteristics ofMolecules (Basel, Switzerland) · 2024Article
- The schizotrophic lifestyle of Sclerotinia sclerotiorum.Molecular plant pathology · 2024Review
- Oxalate and oxalotrophy: an environmental perspective.Sustainable microbiology · 2024Review
- Dual functionality of pathogenesis-related proteins: defensive role in plants versus immunosuppressive role in pathogens.Frontiers in plant science · 2024Article
- Recent advances in virulence of a broad host range plant pathogenFrontiers in microbiology · 2024Review
- Maleic acid and malonic acid reduced the pathogenicity of Sclerotinia sclerotiorum by inhibiting mycelial growth, sclerotia formation and virulence factors.Stress biology · 2023Article
- Molecular characterization of a novel fungal alphaflexivirus reveals potential inter-species horizontal gene transfer.Virus research · 2023Article
- Review
- Genetic breakthroughs in theFrontiers in plant science · 2023Review
- Nitrate reductase is required for sclerotial development and virulence ofFrontiers in plant science · 2023Article
- A cAMP phosphodiesterase is essential for sclerotia formation and virulence inFrontiers in plant science · 2023Article
- Draft genome sequencing and secretome profiling of Sclerotinia sclerotiorum revealed effector repertoire diversity and allied broad-host range necrotrophy.Scientific reports · 2022Article
- Cloning and Molecular Characterization ofJournal of fungi (Basel, Switzerland) · 2022Article
- Selenium Improved Phenylacetic Acid Content in Oilseed Rape and Thus Enhanced the Prevention ofJournal of fungi (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sclerotinia sclerotiorum pathogenesis requires the accumulation of high levels of oxalic acid (OA). To better understand the factors affecting OA accumulation, two putative oxalate decarboxylase (OxDC) genes (Ss-odc1 and Ss-odc2) were characterized. Ss-odc1 transcripts exhibited significant accumulation in vegetative hyphae, apothecia, early stages of compound appressorium development and during plant colonization. Ss-odc2 transcripts, in contrast, accumulated significantly only during mid to late stages of compound appressorium development. Neither gene was induced by low pH or exogenous OA in vegetative hyphae. A loss-of-function mutant for Ss-odc1 (Δss-odc1) showed wild-type growth, morphogenesis and virulence, and was not characterized further. Δss-odc2 mutants hyperaccumulated OA in vitro, were less efficient at compound appressorium differentiation and exhibited a virulence defect which could be fully bypassed by wounding the host plant prior to inoculation. All Δss-odc2 phenotypes were restored to the wild-type by ectopic complementation. An S. sclerotiorum strain overexpressing Ss-odc2 exhibited strong OxDC, but no oxalate oxidase activity. Increasing inoculum nutrient levels increased compound appressorium development, but not penetration efficiency, of Δss-odc2 mutants. Together, these results demonstrate differing roles for S. sclerotiorum OxDCs, with Odc2 playing a significant role in host infection related to compound appressorium formation and function.
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