ArticleExperimental neurology2015
Corticostriatal interactions in the generation of tic-like behaviors after local striatal disinhibition.
Article in Experimental neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 1 of them a synthesis that pooled it.
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Who cites it
46 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Co-morbid tics and stereotypies: a systematic literature review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Pooled it
- In vivo effects of ketamine on glutamate-glutamine and gamma-aminobutyric acid in obsessive-compulsive disorder: Proof of concept.Psychiatry research · 2015Trial
- Tourette syndrome.Nature reviews. Disease primers · 2026Review
- Article
- Tics severity in Tourette syndrome associated with higher glutamatergic activity in the anterior cingulate cortex.Brain communications · 2026Article
- Metabolic abnormalities of the cortico‑striato‑thalamo‑cortical circuit of rats with tic disorder.Molecular medicine reports · 2025Article
- Erasing "bad memories": reversing aberrant synaptic plasticity as therapy for neurological and psychiatric disorders.Molecular psychiatry · 2025Review
- Dissociable roles of central striatum and anterior lateral motor area in initiating and sustaining naturalistic behavior.Cell reports · 2025Article
- Exogenous GABA Alleviates Tourette Syndrome-Like Behavior in Sprague-Dawley Rats by Altering Gut Microbiota and Striatum Metabolism.Neuropsychiatric disease and treatment · 2025Article
- ChangPu YuJin Tang improves Tourette disorder symptoms by modulating amino acid neurotransmitters in IDPN model rats.Metabolic brain disease · 2024Article
- The role of neuroactive steroids in tic disorders.Neuroscience and biobehavioral reviews · 2024Review
- Striatal insights: a cellular and molecular perspective on repetitive behaviors in pathology.Frontiers in cellular neuroscience · 2024Review
- Deep brain stimulation alleviates tics in Tourette syndrome via striatal dopamine transmission.Brain : a journal of neurology · 2023Article
- The Dysfunctional Mechanisms Throwing Tics: Structural and Functional Changes in Tourette Syndrome.Behavioral sciences (Basel, Switzerland) · 2023Review
- Contrasting features between Tourette syndrome and secondary tic disorders.Journal of neural transmission (Vienna, Austria : 1996) · 2023Article
- Selective Activation of D3 Dopamine Receptors Ameliorates DOI-Induced Head Twitching Accompanied by Changes in Corticostriatal Processing.International journal of molecular sciences · 2023Article
- A spiking computational model for striatal cholinergic interneurons.Brain structure & function · 2023Article
- The Sapap3Translational psychiatry · 2023Article
- Enhanced habit formation in Tourette patients explained by shortcut modulation in a hierarchical cortico-basal ganglia model.Brain structure & function · 2022Article
- Frequency and Intensity of Premonitory Urges-to-Tic in Tourette Syndrome Is Associated With Supplementary Motor Area GABA+ Levels.Movement disorders : official journal of the Movement Disorder Society · 2022Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
The pathophysiology of the tics that define Gilles de la Tourette syndrome (TS) is not well understood. Local disinhibition within the striatum has been hypothesized to play a pathogenic role. In support of this, experimental disinhibition by local antagonism of GABA-A receptors within the striatum produces tic-like phenomenology in monkey and rat. We replicated this effect in mice via local picrotoxin infusion into the dorsal striatum. Infusion of picrotoxin into sensorimotor cortex produced similar movements, accompanied by signs of behavioral activation; higher-dose picrotoxin in the cortex produced seizures. Striatal inhibition with local muscimol completely abolished tic-like movements after either striatal or cortical picrotoxin, confirming their dependence on the striatal circuitry; in contrast, cortical muscimol attenuated but did not abolish movements produced by striatal picrotoxin. Striatal glutamate blockade eliminated tic-like movements after striatal picrotoxin, indicating that glutamatergic afferents are critical for their generation. These studies replicate and extend previous work in monkey and rat, providing additional validation for the local disinhibition model of tic generation. Our results reveal a key role for corticostriatal glutamatergic afferents in the generation of tic-like movements in this model.
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