ReviewBioEssays : news and reviews in molecular, cellular and developmental biology2015
Mechanical systems biology of C. elegans touch sensation.
Review in BioEssays : news and reviews in molecular, cellular and developmental biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Article
- Hypergravity hinders proper dendritic patterning of a sensory neuron in the nematode Caenorhabditis elegans.Scientific reports · 2025Article
- Transcriptomic insights into the healthspan-enhancing effects of C. chinensis seed and E. ulmoides bark extracts in Caenorhabditis elegans.Biogerontology · 2025Article
- Obstacles Regulate Membrane Tension Propagation to Enable Localized Mechanotransduction.bioRxiv : the preprint server for biology · 2025Article
- Visualizing Neurons Under Tension In Vivo with Optogenetic Molecular Force Sensors.Methods in molecular biology (Clifton, N.J.) · 2023Article
- An Autonomous Molecular Bioluminescent Reporter (AMBER) for Voltage Imaging in Freely Moving Animals.Advanced biology · 2021Article
- An asymmetric mechanical code ciphers curvature-dependent proprioceptor activity.Science advances · 2021Article
- Mutations in the cell-binding motif ofmicroPublication biology · 2021Article
- Acid-sensing ion channels in sensory signaling.American journal of physiology. Renal physiology · 2020Review
- Shear force sensing of epithelial NaProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Shaping neurodevelopment: distinct contributions of cytoskeletal proteins.Current opinion in neurobiology · 2018Review
- Using a Microfluidics Device for Mechanical Stimulation and High Resolution Imaging of C. elegans.Journal of visualized experiments : JoVE · 2018Article
- Determining the biomechanics of touch sensation in C. elegans.Scientific reports · 2017Article
- Mechanosensation is evolutionarily tuned to locomotor mechanics.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Pneumatic stimulation of C. elegans mechanoreceptor neurons in a microfluidic trap.Lab on a chip · 2017Article
- Genetic defects in β-spectrin and tau sensitizeeLife · 2017Article
- Article
- Microtubule nucleation and organization in dendrites.Cell cycle (Georgetown, Tex.) · 2016Article
- Context Specificity of Stress-activated Mitogen-activated Protein (MAP) Kinase Signaling: The Story as Told by Caenorhabditis elegans.The Journal of biological chemistry · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
The sense of touch informs us of the physical properties of our surroundings and is a critical aspect of communication. Before touches are perceived, mechanical signals are transmitted quickly and reliably from the skin's surface to mechano-electrical transduction channels embedded within specialized sensory neurons. We are just beginning to understand how soft tissues participate in force transmission and how they are deformed. Here, we review empirical and theoretical studies of single molecules and molecular ensembles thought to be involved in mechanotransmission and apply the concepts emerging from this work to the sense of touch. We focus on the nematode Caenorhabditis elegans as a well-studied model for touch sensation in which mechanics can be studied on the molecular, cellular, and systems level. Finally, we conclude that force transmission is an emergent property of macromolecular cellular structures that mutually stabilize one another.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.