ArticleDiabetologia2015
History of infertility and risk of type 2 diabetes mellitus: a prospective cohort study.
Article in Diabetologia, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 2 of them syntheses that pooled it.
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Who cites it
31 citing papers in PubMed, 2 syntheses or guidelines pooled it, 59 citations in OpenAlex.
- Inflammation-mediated effects of diabetes mellitus on male fertility: a systematic review and meta-analysis.Frontiers in endocrinology · 2025Pooled it
- The prevalence of infertility in American Indian/Alaska Natives and other racial/ethnic groups: National Survey of Family Growth.Paediatric and perinatal epidemiology · 2019Pooled it
- Infertility, Gravidity, and Risk Of Diabetes among High-Risk Women in the Diabetes Prevention Program Outcomes Study.The Journal of clinical endocrinology and metabolism · 2020 · on this mapTrial
- History of infertility, risk of type 2 diabetes and HbADiabetologia · 2026Article
- Perceived Risk Perception of Future Cardiovascular Disease and Diabetes in the Postpartum Period.Journal of personalized medicine · 2026Article
- What role do miRNAs play in the injured heart of the infertile female?Biochemistry and biophysics reports · 2025Review
- Lifestyle factors and health outcomes associated with infertility in women: A case-control study using National Health Insurance Database.Reproductive health · 2025Article
- Impact of parity on gestational diabetes mellitus in Chinese women: a retrospective cohort study.BMC pregnancy and childbirth · 2025Article
- Association between infertility and incident onset of systemic autoimmune rheumatic disease after childbirth: a population-based cohort study.Human reproduction (Oxford, England) · 2025Article
- Article
- Impact of hyperglycaemia on cellular microenvironment and function of endometrium and uterine tube: scoping review focused on infertility in diabetic women.Frontiers in cell and developmental biology · 2025Review
- Promoting Healthy Longevity Should Start Young: A Life Course Journey.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2024Article
- Association of infertility with type and timing of menopause: a prospective cohort study.Human reproduction (Oxford, England) · 2023Article
- Self-reported history of comorbidities and markers of ovarian reserve among subfertile women.Journal of assisted reproduction and genetics · 2022Observational
- Characterizing the follicular fluid metabolome: quantifying the correlation across follicles and differences with the serum metabolome.Fertility and sterility · 2022Article
- Gut-Testis Axis: Microbiota Prime Metabolome To Increase Sperm Quality in Young Type 2 Diabetes.Microbiology spectrum · 2022Article
- History of infertility and long-term weight, body composition, and blood pressure among women in Project Viva.Annals of epidemiology · 2022Article
- Pregnancy urinary concentrations of bisphenol A, parabens and other phenols in relation to serum levels of lipid biomarkers: Results from the EARTH study.The Science of the total environment · 2022Article
- Article
- Females with Diabetes Mellitus Increased the Incidence of Premenstrual Syndrome.Life (Basel, Switzerland) · 2022Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 1 country.
Funding
Abstract
aims/hypothesisWe sought to evaluate the relationship between delayed conception and type 2 diabetes risk, given that there are plausible underlying mechanisms linking the two, including inflammation and insulin resistance.
methodsParticipants of the Nurses' Health Study II prospective cohort were included if they were free of chronic disease (cardiovascular disease, type 2 diabetes, cancer) at baseline. Biennial questionnaires updated information on infertility status (>12 months attempted pregnancy), lifestyle characteristics and several health-related outcomes. Self-reported cases of diabetes were confirmed using a follow-up questionnaire. Multivariable Cox proportional hazards models were used to compute the HRs and 95% CIs.
resultsIncident type 2 diabetes occurred in 5,993 of the 112,106 participants over 24 years of follow-up (1989-2013). A history of infertility was reported in 27,774 (24.8%) women and was associated with a 20% greater risk of developing diabetes, compared with those never reporting infertility (HR 1.20 [95% CI 1.14, 1.28]), after adjusting for age, lifestyle factors, marital status, oral contraceptive use, family history of diabetes and BMI. Compared with women without a history of infertility, the causes of infertility associated with a higher diabetes risk were ovulation disorders (HR 1.43 [95% CI 1.29, 1.58]) and tubal factor (HR 1.34 [95% CI 1.13, 1.58]). Cervical factor (HR 1.06 [95% CI 0.81, 1.40]) and endometriosis (HR 1.06 [95% CI 0.89, 1.27]) were not associated, while male factor infertility was associated with a modestly higher diabetes risk (HR 1.15 [95% CI 1.00, 1.33]). CONCLUSIONS/
interpretationThese novel findings suggest a history of infertility, particularly that related to ovulation disorders and tubal blockage, is significantly associated with a higher risk of type 2 diabetes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.