ArticleArchives of oto-rhino-laryngology1989
A subpopulation of outer hair cells possessing GABA receptors with tonotopic organization.
Article in Archives of oto-rhino-laryngology, 1989. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Auditory and electroencephalographic effects of midazolam and alpha-hydroxy-midazolam in healthy subjects.British journal of clinical pharmacology · 2000Trial
- GABAergic synapses between auditory efferent neurons and type II spiral ganglion afferent neurons in the mouse cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Diverse identities and sites of action of cochlear neurotransmitters.Hearing research · 2022Review
- Putative COVID-19 therapies imatinib, lopinavir, ritonavir, and ivermectin cause hair cell damage: A targeted screen in the zebrafish lateral line.Frontiers in cellular neuroscience · 2022Article
- DPOAE Intensity Increase at Individual Dominant Frequency after Short-Term Auditory Exposure.ISRN otolaryngology · 2013Article
- Modulation of hair cell efferents.Hearing research · 2011Review
- The efferent system or olivocochlear function bundle - fine regulator and protector of hearing perception.International journal of biomedical science : IJBS · 2010Article
- Functional role of GABAergic innervation of the cochlea: phenotypic analysis of mice lacking GABA(A) receptor subunits alpha 1, alpha 2, alpha 5, alpha 6, beta 2, beta 3, or delta.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Structure, pharmacology and function of GABA-A receptors in cochlear outer hair cells.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 1993Article
- Cochlear-motor, transduction and signal-transfer tinnitus: models for three types of cochlear tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 1993Review
- gamma-Aminobutyric acid receptor activation of outer hair cells in the guinea pig cochlea.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 1992Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The olivocochlear innervation has been postulated to regulate active mechanical processes in the mammalian cochlea. Histochemical studies led to the suggestion that a subpopulation of these efferent nerves, which predominantly terminate on outer hair cells (OHCs), are gamma-aminobutyric acid (GABA)-ergic. By means of two monoclonal antibodies, we were able to visualize GABAA-receptor immunoreactivity at the basal pole of isolated sensory cells. Both subunits of the GABAA receptor, the alpha- and beta-subunit, are known to form the transmembranous GABA/benzodiazepine-receptor complex and were present on OHCs. In addition, these inhibitory receptors were more numerous in the apical turns of the cochlea, indicating another criterion for distinguishing the apical from basal turns of the cochlea. These results support the concept that a subpopulation of axosomatic synapses at the basal pole of OHCs liberate the inhibitory neurotransmitter GABA into the synaptic cleft. Binding of the transmitter to these newly observed subsynaptic receptors is possibly followed by a change in OHC motility and a subsequent modulation of the movement of the basilar membrane.
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Registered trials
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