ArticleClinical research in cardiology : official journal of the German Cardiac Society2015
Silent ischemic brain lesions after transcatheter aortic valve replacement: lesion distribution and predictors.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Silent Brain Infarction, Delirium, and Cognition in Three Invasive Cardiovascular Procedures: a Systematic Review.Neuropsychology review · 2023Pooled it
- Silent Brain Infarcts Following Cardiac Procedures: A Systematic Review and Meta-Analysis.Journal of the American Heart Association · 2019Pooled it
- Infarct-related structural disconnection and delirium in surgical aortic valve replacement patients.Annals of clinical and translational neurology · 2024Trial
- Trial
- Cerebellar cortical infarct cavities and vertebral artery disease.Neuroradiology · 2016Trial
- Risk factors and prognosis of silent cerebral infarction after transcatheter aortic valve replacement.Scientific reports · 2025Article
- Cerebral ischemic injury after transcatheter aortic valve replacement in patients with pure aortic regurgitation.Journal of Zhejiang University. Science. B · 2023Article
- Cerebral Ischemic Lesions after Transcatheter Aortic Valve Implantation in Patients with Non-Calcific Aortic Stenosis.Journal of clinical medicine · 2022Article
- Embolic Protection with the TriGuard 3 System in Nonagenarian Patients Undergoing Transcatheter Aortic Valve Replacement for Severe Aortic Stenosis.Journal of clinical medicine · 2022Article
- Predictors and neurological consequences of periprocedural cerebrovascular events following transcatheter aortic valve implantation with self-expanding valves.Frontiers in cardiovascular medicine · 2022Article
- Anemia and risk of periprocedural cerebral injury detected by diffusion-weighted magnetic resonance imaging in patients undergoing transcatheter aortic valve replacement.World journal of emergency medicine · 2022Article
- Ischaemic brain changes associated with catheter-based diagnostic cerebral angiography: a diffusion-weighted imaging study.Polish journal of radiology · 2021Article
- Delirium in the Cardiac Intensive Care Unit.Journal of the American Heart Association · 2018Review
- Delirium After Transcatheter Aortic Valve Replacement.American journal of critical care : an official publication, American Association of Critical-Care Nurses · 2017Article
- Rationale and design of the Edwards SAPIEN-3 periprosthetic leakage evaluation versus Medtronic CoreValve in transfemoral aortic valve implantation (ELECT) trial : A randomised comparison of balloon-expandable versus self-expanding transcatheter aortic valve prostheses.Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation · 2017Article
- Thrombosis of TAVI prosthesis-cause for concern or innocent bystander? A comment and review of currently available data.Clinical research in cardiology : official journal of the German Cardiac Society · 2017Article
- Transcatheter aortic valves produce unphysiological flows which may contribute to thromboembolic events: An in-vitro study.Journal of biomechanics · 2016Article
- Pre-operative stroke and neurological disability do not independently affect short- and long-term mortality in infective endocarditis patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
- Neurological damage after transcatheter aortic valve implantation compared with surgical aortic valve replacement in intermediate risk patients.Clinical research in cardiology : official journal of the German Cardiac Society · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsSilent ischemic brain lesions and ischemic stroke are known complications of transcatheter aortic valve replacement (TAVR). We aimed to investigate the occurrence and distribution of TAVR-related silent ischemic brain lesions using diffusion-weighted magnetic resonance imaging (DWI).
methodsConsecutive patients with severe aortic valve stenosis treated with TAVR underwent cerebral DWI within 5 days after the index procedure. DWI scans were analyzed for the occurrence and distribution of new ischemic lesions post-TAVR.
resultsForty-two patients were enrolled in this study. After TAVR, a total of 276 new cerebral ischemic lesions were detected in 38 (90 %) patients, with a median of 4.5 (interquartile range 2.0-7.0) lesions per patient. A total of 129 (47 %) lesions were detected in the cortical regions, 97 (35 %) in the subcortical regions, and 50 (18 %) in the cerebellum or brainstem. The median lesion volume was 20.2 µl (10.0, 42.7) and the total ischemic lesion volume was 132.3 µl (42.8, 336.9). The new ischemic brain lesions were clinically silent in 37 (97 %) patients; the other patient had a transient ischemic attack. Age (B = 0.528, p = 0.015), hyperlipidaemia (B = 5.809, p = 0.028) and post-dilatation of the implanted prosthesis (B = 7.196, p = 0.029) were independently associated with the number of post-TAVR cerebral DWI lesions. In addition, peak transaortic gradient was independently associated with post-procedural total infarct volume.
conclusionClinically silent cerebral infarcts occurred in 90 % of patients following TAVR, most of which were small (<20 μl) and located in the cortical regions of the cerebral hemispheres. An independent association was found between age, hyperlipidaemia and balloon post-dilatation and the number of post-TAVR ischemic brain lesions. Only peak transaortic gradient was independently associated with post-procedural total infarct volume.
Indexed as
Identifiers
25596724What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.